Beclin-1 complex phosphorylates PtdIns

Stable Identifier
R-HSA-5672012
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The Beclin-1 complex (ATG14:PIK3C3:PIK3R4:BECN1) is essential for autophagosome formation (Matsunaga et al. 2009, 2010). PIK3C3 (VPS34), the catalytic component of this complex, is a class III phosphatidylinositol 3-kinase that phosphorylates phosphatidylinositol (PI) producing phosphatidylinositol 3-phosphate (PI3P). PIK3C3 is essential for the early stages of autophagy and colocalizes strongly with early autophagosome markers (Axe et al. 2008). The role of PI3P in autophagosome formation is to recruit WIPI2b (Dooley et al. 2014) a member of the WIPI family (Proikas-Cezanne et al. 2004, 2015, Polson et al. 2010).

Literature References
PubMed ID Title Journal Year
7628435 A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

Volinia, S, Dhand, R, Vanhaesebroeck, B, MacDougall, LK, Stein, R, Zvelebil, MJ, Domin, J, Panaretou, C, Waterfield, MD

EMBO J 1995
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-3-kinase activity of ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created