Reactome | Beclin-1 complex phosphorylates PtdIns

Beclin-1 complex phosphorylates PtdIns

Stable Identifier

R-HSA-5672012

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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The Beclin-1 complex (ATG14:PIK3C3:PIK3R4:BECN1) is essential for autophagosome formation (Matsunaga et al. 2009, 2010). PIK3C3 (VPS34), the catalytic component of this complex, is a class III phosphatidylinositol 3-kinase that phosphorylates phosphatidylinositol (PI) producing phosphatidylinositol 3-phosphate (PI3P). PIK3C3 is essential for the early stages of autophagy and colocalizes strongly with early autophagosome markers (Axe et al. 2008). The role of PI3P in autophagosome formation is to recruit WIPI2b (Dooley et al. 2014) a member of the WIPI family (Proikas-Cezanne et al. 2004, 2015, Polson et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
7628435	A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system Volinia, S, Dhand, R, Vanhaesebroeck, B, MacDougall, LK, Stein, R, Zvelebil, MJ, Domin, J, Panaretou, C, Waterfield, MD	EMBO J	1995