Thr-180 of ULK1 is phosphorylated

Stable Identifier
R-HSA-5672008
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ULK1 phosphorylation activates its kinase activity and leads to the inhibition of mTORC1, via phosphorylation of TSC2 and raptor (Kim et al. 2011). Thr-180 in the activation loop of the catalytic centre of ULK1 is required for ULK1 kinase activity. This is suggested to be an autophosphorylation site, though the existence of an upstream kinase was not ruled out (Bach et al. 2011). A homologous site in yeast Atg1 is similarly required for kinase activity and suggested to be autophosphorylated (Yeh et al. 2010). Ser-1047 at the extreme C-terminal end of mouse ULK1 was proposed to be the main Ulk1 autophosphorylation site (Dorsey et al. 2009); the equivalent residue in human ULK1 is Thr-1046. ULK1-mediated phosphorylations of ATG13, FIP200, and ULK1 itself triggers autophagy (Mizushima et al. 2011).

Literature References
PubMed ID Title Journal Year
21819378 The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

Bach, M, Larance, M, James, DE, Ramm, G

Biochem. J. 2011
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created