p-T38-PPP1R14A binds MLCP

Stable Identifier
R-HSA-5671772
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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p-T38-PPP1R14A binds MLCP
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PPP1R14A (CPI-17) phosphorylated on threonine T38 binds MLCP (myosin light chain phosphatase complex) and inhibits its catalytic activity. PPP1R14A simultanously associates with the MLCP catalytic subunit (PP1CB) and the regulatory subunit MYPT1 (PPP1R12A) (Eto et al. 2004).
Literature References
PubMed ID Title Journal Year
15184667 Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits

Kitazawa, T, Eto, M, Brautigan, DL

Proc. Natl. Acad. Sci. U.S.A. 2004
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Orthologous Events
p-T38-PPP1R14A binds MLCP (Bos taurus)
p-T38-PPP1R14A binds MLCP (Caenorhabditis elegans)
p-T38-PPP1R14A binds MLCP (Canis familiaris)
p-T38-PPP1R14A binds MLCP (Danio rerio)
p-T38-PPP1R14A binds MLCP (Drosophila melanogaster)
p-T38-PPP1R14A binds MLCP (Mus musculus)
p-T38-PPP1R14A binds MLCP (Rattus norvegicus)
p-T38-PPP1R14A binds MLCP (Sus scrofa)
p-T38-PPP1R14A binds MLCP (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-02-03)
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