Reactome | p-T38-PPP1R14A binds MLCP

p-T38-PPP1R14A binds MLCP

Stable Identifier

R-HSA-5671772

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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PPP1R14A (CPI-17) phosphorylated on threonine T38 binds MLCP (myosin light chain phosphatase complex) and inhibits its catalytic activity. PPP1R14A simultanously associates with the MLCP catalytic subunit (PP1CB) and the regulatory subunit MYPT1 (PPP1R12A) (Eto et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15184667	Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits Eto, M, Kitazawa, T, Brautigan, DL	Proc. Natl. Acad. Sci. U.S.A.	2004