p-T38-PPP1R14A binds MLCP

Stable Identifier
R-HSA-5671772
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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p-T38-PPP1R14A binds MLCP
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PPP1R14A (CPI-17) phosphorylated on threonine T38 binds MLCP (myosin light chain phosphatase complex) and inhibits its catalytic activity. PPP1R14A simultanously associates with the MLCP catalytic subunit (PP1CB) and the regulatory subunit MYPT1 (PPP1R12A) (Eto et al. 2004).

Literature References
PubMed ID Title Journal Year
15184667 Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits

Eto, M, Kitazawa, T, Brautigan, DL

Proc. Natl. Acad. Sci. U.S.A. 2004
Participants
Input
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Participant Of
hasEvent
Orthologous Events
p-T38-PPP1R14A binds MLCP (Caenorhabditis elegans)
p-T38-PPP1R14A binds MLCP (Danio rerio)
p-T38-PPP1R14A binds MLCP (Drosophila melanogaster)
p-T38-PPP1R14A binds MLCP (Mus musculus)
p-T38-PPP1R14A binds MLCP (Rattus norvegicus)
p-T38-PPP1R14A binds MLCP (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-02-03)