p-T38-PPP1R14A binds MLCP

Stable Identifier
R-HSA-5671772
Type
Reaction
Species
Homo sapiens
Compartment
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PPP1R14A (CPI-17) phosphorylated on threonine T38 binds MLCP (myosin light chain phosphatase complex) and inhibits its catalytic activity. PPP1R14A simultanously associates with the MLCP catalytic subunit (PP1CB) and the regulatory subunit MYPT1 (PPP1R12A) (Eto et al. 2004).

Literature References
PubMed ID Title Journal Year
15184667 Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits

Kitazawa, T, Eto, M, Brautigan, DL

Proc. Natl. Acad. Sci. U.S.A. 2004
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