p-T774-PKN1 phosphorylates PPP1R14A

Stable Identifier
R-HSA-5671763
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated PKN1 (p-T774-PKN1) phosphorylates PPP1R14A (CPI-17), an inhibitor of myosin light chain phosphatase complex (MLPC), on threonine residue T38 (Hamaguchi et al. 2000), and high levels of PKN1 activity correlate with high levels of PPP1R14A phosphorylation (Lartey et al. 2007). It is not certain that PKN1 can directly bind PPP1R14A, and C family protein kinases (PKCs) may be the main PPP1R14A kinases (Zemlickova et al. 2004).

Literature References
PubMed ID Title Journal Year
17301291 Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor

Lartey, J, Smith, M, Pawade, J, Strachan, B, Mellor, H, López Bernal, A

Biol. Reprod. 2007
15003508 Association of CPI-17 with protein kinase C and casein kinase I

Zemlickova, E, Johannes, FJ, Aitken, A, Dubois, T

Biochem. Biophys. Res. Commun. 2004
10924361 Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N

Hamaguchi, T, Ito, M, Feng, J, Seko, T, Koyama, M, Machida, H, Takase, K, Amano, M, Kaibuchi, K, Hartshorne, DJ, Nakano, T

Biochem. Biophys. Res. Commun. 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T774-PKN1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created