p-T774-PKN1 phosphorylates PPP1R14A

Stable Identifier
Reaction [transition]
Homo sapiens
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Activated PKN1 (p-T774-PKN1) phosphorylates PPP1R14A (CPI-17), an inhibitor of myosin light chain phosphatase complex (MLPC), on threonine residue T38 (Hamaguchi et al. 2000), and high levels of PKN1 activity correlate with high levels of PPP1R14A phosphorylation (Lartey et al. 2007). It is not certain that PKN1 can directly bind PPP1R14A, and C family protein kinases (PKCs) may be the main PPP1R14A kinases (Zemlickova et al. 2004).
Literature References
PubMed ID Title Journal Year
15003508 Association of CPI-17 with protein kinase C and casein kinase I

Dubois, T, Johannes, FJ, Zemlickova, E, Aitken, A

Biochem. Biophys. Res. Commun. 2004
17301291 Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor

Strachan, B, Lartey, J, Smith, M, Mellor, H, Pawade, J, López Bernal, A

Biol. Reprod. 2007
10924361 Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N

Hartshorne, DJ, Kaibuchi, K, Seko, T, Ito, M, Feng, J, Nakano, T, Takase, K, Machida, H, Koyama, M, Hamaguchi, T, Amano, M

Biochem. Biophys. Res. Commun. 2000
Catalyst Activity

protein serine/threonine kinase activity of p-T774-PKN1 [cytosol]

Orthologous Events
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