Reactome | p-T774-PKN1 phosphorylates CDC25C

p-T774-PKN1 phosphorylates CDC25C

Stable Identifier

R-HSA-5671749

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Activated PKN1 (p-T774-PKN1) phosphorylates CDC25C on serine residue S216. This leads to increased binding of CDC25C to 14-3-3 proteins, retention of CDC25C in the cytosol, and delayed mitotic entry (Misaki et al. 2001, Isigawa et al. 2005, Collazos et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
15791647	Involvement of protein kinase PKN1 in G2/M delay caused by arsenite Isagawa, T, Takahashi, M, Kato, T, Mukai, H, Ono, Y	Mol. Carcinog.	2005
21749319	Site recognition and substrate screens for PKN family proteins Collazos, A, Michael, N, Whelan, RD, Kelly, G, Mellor, H, Pang, LC, Totty, N, Parker, PJ	Biochem. J.	2011
11134534	PKN delays mitotic timing by inhibition of Cdc25C: possible involvement of PKN in the regulation of cell division Misaki, K, Mukai, H, Yoshinaga, C, Oishi, K, Isagawa, T, Takahashi, M, Ohsumi, K, Kishimoto, T, Ono, Y	Proc. Natl. Acad. Sci. U.S.A.	2001