Activated PKN1 (p-T774-PKN1) phosphorylates CDC25C on serine residue S216. This leads to increased binding of CDC25C to 14-3-3 proteins, retention of CDC25C in the cytosol, and delayed mitotic entry (Misaki et al. 2001, Isigawa et al. 2005, Collazos et al. 2011).
Kato, T, Ono, Y, Mukai, H, Isagawa, T, Takahashi, M
Kelly, G, Pang, LC, Mellor, H, Michael, N, Totty, N, Whelan, RD, Parker, PJ, Collazos, A
Misaki, K, Kishimoto, T, Ohsumi, K, Oishi, K, Takahashi, M, Isagawa, T, Mukai, H, Yoshinaga, C, Ono, Y
protein kinase C activity of p-T774-PKN1:CDC25C [cytosol]
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