p-T774-PKN1 phosphorylates CDC25C

Stable Identifier
R-HSA-5671749
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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Summation

Activated PKN1 (p-T774-PKN1) phosphorylates CDC25C on serine residue S216. This leads to increased binding of CDC25C to 14-3-3 proteins, retention of CDC25C in the cytosol, and delayed mitotic entry (Misaki et al. 2001, Isigawa et al. 2005, Collazos et al. 2011).

Literature References
PubMed ID Title Journal Year
21749319 Site recognition and substrate screens for PKN family proteins

Collazos, A, Michael, N, Whelan, RD, Kelly, G, Mellor, H, Pang, LC, Totty, N, Parker, PJ

Biochem. J. 2011
15791647 Involvement of protein kinase PKN1 in G2/M delay caused by arsenite

Isagawa, T, Takahashi, M, Kato, T, Mukai, H, Ono, Y

Mol. Carcinog. 2005
11134534 PKN delays mitotic timing by inhibition of Cdc25C: possible involvement of PKN in the regulation of cell division

Misaki, K, Mukai, H, Yoshinaga, C, Oishi, K, Isagawa, T, Takahashi, M, Ohsumi, K, Kishimoto, T, Ono, Y

Proc. Natl. Acad. Sci. U.S.A. 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T774-PKN1:CDC25C [cytosol]
Physical Entity
p-T774-PKN1:CDC25C [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
p-T774-PKN1 phosphorylates CDC25C (Bos taurus)
p-T774-PKN1 phosphorylates CDC25C (Caenorhabditis elegans)
p-T774-PKN1 phosphorylates CDC25C (Canis familiaris)
p-T774-PKN1 phosphorylates CDC25C (Dictyostelium discoideum)
p-T774-PKN1 phosphorylates CDC25C (Drosophila melanogaster)
p-T774-PKN1 phosphorylates CDC25C (Mus musculus)
p-T774-PKN1 phosphorylates CDC25C (Rattus norvegicus)
p-T774-PKN1 phosphorylates CDC25C (Saccharomyces cerevisiae)
p-T774-PKN1 phosphorylates CDC25C (Schizosaccharomyces pombe)
p-T774-PKN1 phosphorylates CDC25C (Sus scrofa)
p-T774-PKN1 phosphorylates CDC25C (Xenopus tropicalis)
Authored