Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA

Stable Identifier
Reaction [transition]
Homo sapiens
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Neutrophil gelatinase-associated lipocalin (LCN2, NGAL) is a member of the lipocalin superfamily that is involved in iron trafficking both in and out of cells (Goetz et al. 2002). LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. The iron-bound form of LCN2 (holo-LCN2) is internalised following binding to the solute carrier family 22 member 17 (SLC22A17) receptor, leading to release of iron which increases intracellular iron concentration and subsequent inhibition of apoptosis. This step is inferred from experiments using the highly homologous 24p3 mouse lipocalin and 24p3R mouse cell surface receptor (Devireddy et al. 2005).
Literature References
PubMed ID Title Journal Year
12453412 The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition

Raymond, KN, Bluhm, ME, Goetz, DH, Strong, RK, Holmes, MA, Borregaard, N

Mol. Cell 2002
16377569 A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake

Zhu, X, Gazin, C, Green, MR, Devireddy, LR

Cell 2005
15531878 Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Aderem, A, Rodriguez, DJ, Flo, TH, Sato, S, Strong, RK, Akira, S, Holmes, MA, Smith, KD

Nature 2004
Catalyst Activity

transmembrane transporter activity of SLC22A17 [plasma membrane]

Orthologous Events
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