Reactome | AP1G2 binds HGS and CHMP2A

AP1G2 binds HGS and CHMP2A

Stable Identifier

R-HSA-5671702

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

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AP-1 complex subunit gamma-like 2 (AP1G2) is an 87-kDa protein that is similar to gamma-adaptin (AP1G1), a large chain of the AP1 clathrin-associated adaptor complex, both in primary structure (60% amino acid identity) and domain organisation (Takatsu et al. 1998). AP1G2 can be viewed as a putative endosomal sorting and trafficking adaptor that is specifically required for degradative endocytic trafficking and may help in maintaining homeostasis of the multivesicular body (MVB) protein-sorting pathway. AP1G2 specifically interacts with the core ESCRT subunits hepatocyte growth factor-regulated tyrosine kinase substrate (HGS, aka HRS) and charged multivesicular body protein 2a (CHMP2A aka hVps2-1), involved in MVB processing (Doring et al. 2010).

AP1G2 is also able to bind the large envelope protein (surface protein S) of the hepatitis B virus (HBV), a protein that plays an important role in viral budding (Hartmann-Stuhler & Prange 2001). Disruption of this binding can inhibit virus production (Rost et al. 2006). Thus, AP1G2 may play a role in L-mediated processes of viral biogenesis or pathogenesis.

Literature References

PubMed ID	Title	Journal	Year
11333915	Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein Hartmann-Stühler, C, Prange, R	J. Virol.	2001
20708039	?2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits Prange, R, Stieler, J, Döring, T, Gotthardt, K	Biochim. Biophys. Acta	2010
9733768	Identification and characterization of novel clathrin adaptor-related proteins Murakami, K, Nakayama, K, Takatsu, H, Sakurai, M, Shin, HW	J. Biol. Chem.	1998
16867982	Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation Prange, R, Thomé, N, Rost, M, Döring, T, Lambert, C, Mann, S	J. Biol. Chem.	2006