Reactome | EDA-3 [plasma membrane]

EDA-3 [plasma membrane]

Stable Identifier

R-HSA-5669079

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ectodysplasin-A, EDA_HUMAN, EDA A2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q92838-3 EDA

Gene Names

EDA, ED1, EDA2

Other Identifiers

11728157_at

11728158_at

11735891_a_at

11738669_at

11742320_at

11742321_x_at

11742331_x_at

11752858_x_at

17104387

1896

206217_PM_at

206217_at

211127_PM_x_at

211127_x_at

211128_PM_at

211128_at

211129_3p_x_at

211129_PM_x_at

211129_x_at

211130_3p_x_at

211130_PM_x_at

211130_x_at

211131_PM_s_at

211131_s_at

37139_at

37140_s_at

3980381

3980382

3980383

3980384

3980385

3980386

3980387

3980388

3980389

3980390

3980395

3980396

3980399

3980401

3980415

3980416

3980418

3980419

3980420

3980421

3980422

3980429

3980430

3980431

3980433

3980434

3980435

3980436

3980437

3980441

3980443

8168062

A_14_P129658

A_23_P34045

A_24_P100419

A_33_P3303572

GE58253

GO:0001942

GO:0002376

GO:0005102

GO:0005123

GO:0005125

GO:0005164

GO:0005515

GO:0005576

GO:0005581

GO:0005615

GO:0005789

GO:0005811

GO:0005856

GO:0005886

GO:0006955

GO:0007154

GO:0007155

GO:0007160

GO:0007165

GO:0010467

GO:0010628

GO:0016020

GO:0019221

GO:0023052

GO:0030154

GO:0038177

GO:0042475

GO:0043123

GO:0043226

GO:0043231

GO:0043473

GO:0043588

GO:0045177

GO:0048018

GO:0048513

GO:0048856

GO:0060070

GO:0060662

GO:0060789

GO:0061153

GO:0090263

GO:0098772

GO:1901222

GO:1901224

HMNXSV003039437

ILMN_1671633

ILMN_1684000

ILMN_1709975

ILMN_1791250

ILMN_2381655

PH_hs_0031501

U59228_at

g3779247_3p_a_at

g3779249_3p_at

g3779251_3p_a_at

g3779253_3p_a_at

g4503448_3p_at

Participates

as a component of

EDA-3:EDA2R [plasma membrane] (Homo sapiens)

as an input of

EDA-3 binds EDA2R (Homo sapiens)

Inferred To

EDA [plasma membrane] (Bos taurus)

EDA [plasma membrane] (Canis familiaris)

EDA [plasma membrane] (Gallus gallus)

EDA [plasma membrane] (Sus scrofa)

egr [plasma membrane] (Drosophila melanogaster)

Eda [plasma membrane] (Mus musculus)

Eda [plasma membrane] (Rattus norvegicus)

eda [plasma membrane] (Danio rerio)

eda [plasma membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000432585, ENSP00000340611, ENST00000525810, ENST00000374553, ENSP00000363681, ENST00000374552, ENSP00000434861, ENSP00000363680, ENSP00000434195, ENST00000338901, ENST00000527388, ENST00000524573

OpenTargets

ENSG00000158813

HPA

ENSG00000158813-EDA

PRO

Q92838

Pharos - Targets

Q92838

GlyGen

Q92838

Orphanet

EDA

PDB

1RJ8, 1RJ7, 7X9G

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26678 PLN	2	p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813) PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319)	0.886	11
UniProt:Q6P499 NIPAL3	1	NIPAL3 [plasma membrane] (R-HSA-5215974)	0.781	8
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.781	7
UniProt:P21145 MAL			0.781	7
UniProt:P54852 EMP3			0.781	7
UniProt:Q96F15 GIMA5			0.718	6
UniProt:P49447 CY561			0.718	6
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.718	6
UniProt:O95214 LERL1			0.666	4
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.666	4
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:Q4LDR2 CTXN3			0.556	3
UniProt:Q9UBY5 LPAR3	1	LPAR3 [plasma membrane] (R-HSA-419379)	0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q5J8X5 M4A13			0.556	3
UniProt:Q69YG0 TMM42			0.556	3
UniProt:P56557 TM50B			0.556	3
UniProt:Q9NRP0 OSTC			0.556	3
UniProt:Q8TBU1 Q8TBU1			0.556	3
UniProt:Q9NVC3 S38A7			0.556	3
UniProt:Q6FHL7 Q6FHL7			0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3