TWEAK binds FN14

Stable Identifier
R-HSA-5669023
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
TNFSF12 binds TNFRSF12A
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The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK or TNFSF12) is a member of the TNF superfamily (TNFSF) that contribute to acute kidney injury (AKI) and chronic kidney disorder (CKD), where it has been shown to regulate cell death, inflammation, and fibrosis through activation of the TWEAK receptor fibroblast growth factor-inducible 14 (FN14 or TNFRSF12A). FN14 (TNFRSF12A) is a type I transmembrane and the smallest member of the TNF receptor super family. TWEAK mediates NF-kappaB activation to promote angiogenesis and the proliferation of endothelial cells via its binding to FN14 (TNFSF12A) (Poveda et al. 2013, Lynch et al. 1999, Wiley et al. 2001, Wiley & Winkles 2003). Both membrane bound and soluble forms of TWEAK form homotrimers and have been shown to be able to bind to three monomers of receptor FN14 and trigger signalling (Roos et al. 2010).

Literature References
PubMed ID Title Journal Year
11728344 A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis

Wiley, SR, Cassiano, L, Lofton, T, Davis-Smith, T, Winkles, JA, Lindner, V, Liu, H, Daniel, TO, Smith, CA, Fanslow, WC

Immunity 2001
12787562 TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor

Wiley, SR, Winkles, JA

Cytokine Growth Factor Rev. 2003
20385556 Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway

Brown, SA, Ghosh, A, Winkles, JA

J. Biol. Chem. 2010
23667509 Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding

Lammens, A, Baehner, M, Kohnert, U, Niewoehner, J, von Proff, L, Schraeml, M, Lammens, K, Hopfner, KP

PLoS ONE 2013
10085077 TWEAK induces angiogenesis and proliferation of endothelial cells

Lynch, CN, Wang, YC, Lund, JK, Chen, YW, Leal, JA, Wiley, SR

J. Biol. Chem. 1999
19241374 Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily

He, F, Dang, W, Saito, K, Watanabe, S, Kobayashi, N, G√ľntert, P, Kigawa, T, Tanaka, A, Muto, Y, Yokoyama, S

Protein Sci. 2009
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