Reactome | PAK1 or PAK2 phosphorylates MYLK

PAK1 or PAK2 phosphorylates MYLK

Stable Identifier

R-HSA-5668984

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PAK1 and PAK2 phosphorylate and inactivate MYLK (MLCK), a myosin light chain kinase. It is assumed that PAK1 phosphorylates the same sites as PAK2. MYLK serine residues phosphorylated by PAK2 were determined using rabbit recombinant MYLK and human PAK2. Rabbit MYLK serines S439 and S991 are conserved in human MYLK and match S1208 and S1759 (Sanders et al. 1999, Goeckeler et al. 2000). Please note that the recombinant rabbit MYLK sequence is shorter than the canonical human MYLK sequence and corresponds to human MYLK transcription isoforms that lack the first 922 amino acids present in the canonical MYLK isoform.

Literature References

PubMed ID	Title	Journal	Year
10092231	Inhibition of myosin light chain kinase by p21-activated kinase Matsumura, F, Bokoch, GM, Sanders, LC, de Lanerolle, P	Science	1999
10748018	Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2 Zeng, Q, Masaracchia, RA, Chew, TL, Wysolmerski, RB, Gallagher, P, Goeckeler, ZM	J Biol Chem	2000