PAK1 phosphorylates myosin phosphatase

Stable Identifier
R-HSA-5668947
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PAK1 phosphorylates the regulatory subunit MYPT1 (PPP1R12A) of the myosin phosphatase complex on threonine residue T696, thereby inhibiting the catalytic activity of the myosin phosphatase and indirectly increasing phosphorylation of the myosin regulatory light chain (MRLC) (Chu et al. 2013).

Literature References
PubMed ID Title Journal Year
23161543 Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility

Chu, J, Pham, NT, Olate, N, Kislitsyna, K, Day, MC, LeTourneau, PA, Kots, A, Stewart, RH, Laine, GA, Cox, CS, Uray, K

J. Biol. Chem. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S144,T423-PAK1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created