PAK1 phosphorylates myosin phosphatase

Stable Identifier
R-HSA-5668947
Type
Reaction
Species
Homo sapiens
Compartment
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PAK1 phosphorylates the regulatory subunit MYPT1 (PPP1R12A) of the myosin phosphatase complex on threonine residue T696, thereby inhibiting the catalytic activity of the myosin phosphatase and indirectly increasing phosphorylation of the myosin regulatory light chain (MRLC) (Chu et al. 2013).

Literature References
PubMed ID Title Journal Year
23161543 Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility

Stewart, RH, LeTourneau, PA, Chu, J, Kislitsyna, K, Kots, A, Day, MC, Olate, N, Uray, K, Laine, GA, Cox, CS, Pham, NT

J. Biol. Chem. 2013
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S144,T423-PAK1 [cytosol]

Orthologous Events
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Created
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