PAK2 phosphorylates myosin regulatory light chain (MRLC)

Stable Identifier
R-HSA-5668932
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PAK2, activated by CDC42 or RAC1 RHO GTPases, phosphorylates myosin regulatory light chain (MRLC, MYL9 or MYL12B) of the non-muscle myosin II complex on threonine residue T19 (also labeled in literature as T18). This leads to the rearrangement of the actin cytoskeleton and cell retraction (Chew et al. 1998, Zeng et al. 2000).

Literature References
PubMed ID Title Journal Year
10639334 Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II

Zeng, Q, Lagunoff, D, Masaracchia, R, Goeckeler, Z, Côté, G, Wysolmerski, R

J. Cell. Sci. 2000
10047984 Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK)

Chew, TL, Masaracchia, RA, Goeckeler, ZM, Wysolmerski, RB

J. Muscle Res. Cell. Motil. 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S141,T402-PAK2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created