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TNFRSF11A [plasma membrane]
Stable Identifier
R-HSA-5668756
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RANK, Tumor necrosis factor receptor superfamily member 11A, TNR11_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
2xRANK binds RANKL,sRANKL trimer:RANK (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
RANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer binds RANK (Homo sapiens)
RANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
TRAFs bind RANK:RANKL (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
TNFRSF11A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6Q6 TNFRSF11A
Gene Names
TNFRSF11A, RANK
Chain
signal peptide:1-29, chain:30-616
Reference Genes
BioGPS Gene:8792 TNFRSF11A
COSMIC (genes):TNFRSF11A TNFRSF11A
CTD Gene:8792 TNFRSF11A
dbSNP Gene:8792 TNFRSF11A
ENSEMBL:ENSG00000141655 TNFRSF11A
HGNC:11908 TNFRSF11A
KEGG Gene (Homo sapiens):8792 TNFRSF11A
Monarch:8792 TNFRSF11A
NCBI Gene:8792 TNFRSF11A
OMIM:603499 TNFRSF11A
UCSC:Q9Y6Q6 TNFRSF11A
Reference Transcript
RefSeq:NM_001270950.1 TNFRSF11A
RefSeq:NM_003839.3 TNFRSF11A
RefSeq:NM_001278268.1 TNFRSF11A
RefSeq:NM_001270951.1 TNFRSF11A
RefSeq:NM_001270949.1 TNFRSF11A
Other Identifiers
0006100364
11735293_x_at
16852760
207037_PM_at
207037_at
238846_PM_at
238846_at
32479_at
3791255
3791256
3791273
3791277
3791279
3791280
3791282
3791283
3791286
3791287
3791288
3791289
3791296
3791297
3791298
3791299
3791300
3791301
3791302
3791303
3791304
3791306
8021528
86750_at
8792
A_14_P100206
A_23_P390518
A_24_P211106
GE562184
GO:0001503
GO:0002250
GO:0002376
GO:0002548
GO:0003674
GO:0004888
GO:0005031
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006810
GO:0006950
GO:0007165
GO:0007267
GO:0008150
GO:0008283
GO:0008284
GO:0009058
GO:0009314
GO:0009897
GO:0009986
GO:0016020
GO:0016021
GO:0019955
GO:0030154
GO:0030316
GO:0032496
GO:0033209
GO:0034097
GO:0034612
GO:0034641
GO:0038023
GO:0040011
GO:0042592
GO:0043167
GO:0043507
GO:0045780
GO:0046872
GO:0048535
GO:0048856
GO:0048870
GO:0051091
GO:0051092
GO:0060086
GO:0060749
GO:0070555
GO:0071812
GO:0071847
GO:0071848
GO:0072674
HMNXSV003058256
Hs.204044.0.A1_3p_at
ILMN_1698952
PH_hs_0023025
PH_hs_0039610
TC18000221.hg
g4507564_3p_at
Participates
as an input of
RANKL,sRANKL trimer binds RANK (Homo sapiens)
2xRANK binds RANKL,sRANKL trimer:RANK (Homo sapiens)
as a component of
RANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
Inferred To
TNFRSF11A [plasma membrane]
(Bos taurus)
TNFRSF11A [plasma membrane]
(Canis familiaris)
TNFRSF11A [plasma membrane]
(Gallus gallus)
TNFRSF11A [plasma membrane]
(Sus scrofa)
tnfrsf11a [plasma membrane]
(Danio rerio)
Tnfrsf11a [plasma membrane]
(Mus musculus)
Tnfrsf11a [plasma membrane]
(Rattus norvegicus)
Ghost homologue of TNFRSF11A [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001257878.1
,
NP_001257880.1
,
NP_003830.1
,
NP_001257879.1
,
NP_001265197.1
Guide to Pharmacology - Targets
1881
OpenTargets
ENSG00000141655
GeneCards
Q9Y6Q6
HPA
ENSG00000141655-TNFRSF11A
Ensembl
ENSP00000482466
,
ENST00000617039
,
ENSG00000141655
,
ENSP00000479567
,
ENST00000616710
,
ENSP00000269485
,
ENST00000586569
,
ENST00000269485
,
ENSP00000465500
PRO
Q9Y6Q6
Pharos - Targets
Q9Y6Q6
Orphanet
15633
PDB
1LB5
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14788-PRO_0000034515 TNFSF11
0.611
9
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.589
2
UniProt:O00300 TNFRSF11B
1
TNFRSF11B [plasma membrane]
(R-HSA-5672848)
0.544
7
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