NOX3 complex:RAC1:GTP generates superoxide from oxygen

Stable Identifier
R-HSA-5668731
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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While NOX3:CYBA complex has constitutive NADPH oxidase activity, the presence of NCF1, NCF2 or NOXA1 and RAC1:GTP enhances the production of superoxide O2- by the NOX3:CYBA complex. When NCF1 is replaced with NOXO1, RAC1:GTP becomes dispensible for the full activation of the NOX3 complex (Ueno et al. 2005, Ueyama et al. 2006, Miyano and Sumimoto 2007, Kao et al. 2008)

Literature References
PubMed ID Title Journal Year
15824103 The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators

Ueno, N, Takeya, R, Miyano, K, Kikuchi, H, Sumimoto, H

J. Biol. Chem. 2005
16507994 Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases

Ueyama, T, Geiszt, M, Leto, TL

Mol. Cell. Biol. 2006
18347018 Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism

Kao, YY, Gianni, D, Bohl, B, Taylor, RM, Bokoch, GM

J. Biol. Chem. 2008
17583407 Role of the small GTPase Rac in p22phox-dependent NADPH oxidases

Miyano, K, Sumimoto, H

Biochimie 2007
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Catalyst Activity
Catalyst Activity
Title
superoxide-generating NADPH oxidase activity of NOX3 complex:RAC1:GTP [plasma membrane]
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Activity
Orthologous Events
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Created