NOX1 complex:RAC1:GTP generates superoxide from oxygen

Stable Identifier
R-HSA-5668718
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The activity of the non-phagocytic NADPH oxidase 1 (NOX1) complex, composed of NOX1, NOXA1, NOXO1 and CYBA, is greatly enhanced upon RAC1:GTP binding, resulting in production of the superoxide O2- which can serve as a second messenger (Takeya et al. 2003, Miyano et al. 2006, Park et al. 2006, Cheng et al. 2006).

Literature References
PubMed ID Title Journal Year
16329988 Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1

Park, HS, Park, D, Bae, YS

Biochem. Biophys. Res. Commun. 2006
16636067 Nox1-dependent reactive oxygen generation is regulated by Rac1

Cheng, G, Diebold, BA, Hughes, Y, Lambeth, JD

J. Biol. Chem. 2006
16762923 Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1

Miyano, K, Ueno, N, Takeya, R, Sumimoto, H

J. Biol. Chem. 2006
12716910 Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases

Takeya, R, Ueno, N, Kami, K, Taura, M, Kohjima, M, Izaki, T, Nunoi, H, Sumimoto, H

J. Biol. Chem. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
superoxide-generating NADPH oxidase activity of NOX1 complex:RAC1:GTP [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created