Reactome | NOX1 complex:RAC1:GTP generates superoxide from oxygen

NOX1 complex:RAC1:GTP generates superoxide from oxygen

Stable Identifier

R-HSA-5668718

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

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NOX1 complex:RAC1:GTP generates superoxide from oxygen

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The activity of the non-phagocytic NADPH oxidase 1 (NOX1) complex, composed of NOX1, NOXA1, NOXO1 and CYBA, is greatly enhanced upon RAC1:GTP binding, resulting in production of the superoxide O2- which can serve as a second messenger (Takeya et al. 2003, Miyano et al. 2006, Park et al. 2006, Cheng et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16329988	Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1 Park, HS, Park, D, Bae, YS	Biochem. Biophys. Res. Commun.	2006
16636067	Nox1-dependent reactive oxygen generation is regulated by Rac1 Cheng, G, Diebold, BA, Hughes, Y, Lambeth, JD	J. Biol. Chem.	2006
16762923	Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1 Miyano, K, Ueno, N, Takeya, R, Sumimoto, H	J. Biol. Chem.	2006
12716910	Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases Takeya, R, Ueno, N, Kami, K, Taura, M, Kohjima, M, Izaki, T, Nunoi, H, Sumimoto, H	J. Biol. Chem.	2003