The activity of the non-phagocytic NADPH oxidase 1 (NOX1) complex, composed of NOX1, NOXA1, NOXO1 and CYBA, is greatly enhanced upon RAC1:GTP binding, resulting in production of the superoxide O2- which can serve as a second messenger (Takeya et al. 2003, Miyano et al. 2006, Park et al. 2006, Cheng et al. 2006).
Park, HS, Park, D, Bae, YS
Cheng, G, Diebold, BA, Hughes, Y, Lambeth, JD
Miyano, K, Ueno, N, Takeya, R, Sumimoto, H
Takeya, R, Ueno, N, Kami, K, Taura, M, Kohjima, M, Izaki, T, Nunoi, H, Sumimoto, H
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