RAC1:GTP binds NOX1 complex

Stable Identifier
R-HSA-5668714
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated RAC1 (RAC1:GTP) binds NADPH oxidase NOX1 complex composed of NOX1, NOXA1, NOXO1 and CYBA (p22phox). RAC1 directly interacts with a conserved region in NOX1 and with tetratricopeptide repeats in NOXA1 (Takeya et al. 2003, Park et al. 2006, Cheng et al. 2006, Myano et al. 2006, Kao et al. 2008)

Literature References
PubMed ID Title Journal Year
16329988 Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1

Park, HS, Park, D, Bae, YS

Biochem. Biophys. Res. Commun. 2006
16636067 Nox1-dependent reactive oxygen generation is regulated by Rac1

Cheng, G, Diebold, BA, Hughes, Y, Lambeth, JD

J. Biol. Chem. 2006
16762923 Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1

Miyano, K, Ueno, N, Takeya, R, Sumimoto, H

J. Biol. Chem. 2006
18347018 Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism

Kao, YY, Gianni, D, Bohl, B, Taylor, RM, Bokoch, GM

J. Biol. Chem. 2008
12716910 Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases

Takeya, R, Ueno, N, Kami, K, Taura, M, Kohjima, M, Izaki, T, Nunoi, H, Sumimoto, H

J. Biol. Chem. 2003
Participants
Participant Of
Orthologous Events
Authored
Created