RAC2:GTP binds NOX2 complex

Stable Identifier
R-HSA-5668605
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In neutrophils, RAC2 regulates NADPH oxidase NOX2 complex (Knaus et al. 1991, Kim et al. 2001) which consists of CYBB (NOX2), CYBA (p22phox), NCF1 (p47phox), NCF2 (p67phox) and NCF4 (p40phox). GTP-bound RAC2 binds to a conserved region of CYBB and tetratricopeptide repeats of NCF2 (Koga et al. 1999, Lapouge et al. 2000, Kao et al. 2008).

Literature References
PubMed ID Title Journal Year
11145705 Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways

Kim, C, Dinauer, MC

J. Immunol. 2001
11090627 Structure of the TPR domain of p67phox in complex with Rac.GTP

Lapouge, K, Smith, SJ, Walker, PA, Gamblin, SJ, Smerdon, SJ, Rittinger, K

Mol. Cell 2000
10455184 Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase

Koga, H, Terasawa, H, Nunoi, H, Takeshige, K, Inagaki, F, Sumimoto, H

J. Biol. Chem. 1999
1660188 Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2

Knaus, UG, Heyworth, PG, Evans, T, Curnutte, JT, Bokoch, GM

Science 1991
18347018 Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism

Kao, YY, Gianni, D, Bohl, B, Taylor, RM, Bokoch, GM

J. Biol. Chem. 2008
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