In neutrophils, RAC2 regulates NADPH oxidase NOX2 complex (Knaus et al. 1991, Kim et al. 2001) which consists of CYBB (NOX2), CYBA (p22phox), NCF1 (p47phox), NCF2 (p67phox) and NCF4 (p40phox). GTP-bound RAC2 binds to a conserved region of CYBB and tetratricopeptide repeats of NCF2 (Koga et al. 1999, Lapouge et al. 2000, Kao et al. 2008).
Kim, C, Dinauer, MC
Lapouge, K, Smith, SJ, Walker, PA, Gamblin, SJ, Smerdon, SJ, Rittinger, K
Koga, H, Terasawa, H, Nunoi, H, Takeshige, K, Inagaki, F, Sumimoto, H
Knaus, UG, Heyworth, PG, Evans, T, Curnutte, JT, Bokoch, GM
Kao, YY, Gianni, D, Bohl, B, Taylor, RM, Bokoch, GM
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