Reactome | RAC2:GTP binds NOX2 complex

RAC2:GTP binds NOX2 complex

Stable Identifier

R-HSA-5668605

Type

Reaction [binding]

Species

Homo sapiens

Compartment

phagocytic vesicle membrane

ReviewStatus

5/5

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In neutrophils, RAC2 regulates NADPH oxidase NOX2 complex (Knaus et al. 1991, Kim et al. 2001) which consists of CYBB (NOX2), CYBA (p22phox), NCF1 (p47phox), NCF2 (p67phox) and NCF4 (p40phox). GTP-bound RAC2 binds to a conserved region of CYBB and tetratricopeptide repeats of NCF2 (Koga et al. 1999, Lapouge et al. 2000, Kao et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
11090627	Structure of the TPR domain of p67phox in complex with Rac.GTP Lapouge, K, Smith, SJ, Walker, PA, Gamblin, SJ, Smerdon, SJ, Rittinger, K	Mol. Cell	2000
11145705	Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways Kim, C, Dinauer, MC	J. Immunol.	2001
10455184	Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase Koga, H, Terasawa, H, Nunoi, H, Takeshige, K, Inagaki, F, Sumimoto, H	J. Biol. Chem.	1999
1660188	Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2 Knaus, UG, Heyworth, PG, Evans, T, Curnutte, JT, Bokoch, GM	Science	1991
18347018	Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism Kao, YY, Gianni, D, Bohl, B, Taylor, RM, Bokoch, GM	J. Biol. Chem.	2008