Reactome | Protesomal degradation of K48polyUb-TRAF3

Protesomal degradation of K48polyUb-TRAF3

Stable Identifier

R-HSA-5668481

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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Protesomal degradation of K48polyUb-TRAF3

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K48-linked ubiquitination of TRAF3 further leads to its proteasome-dependent degradation. The resultant degradation of TRAF3 releases NIK from the cIAPs ubiquitin-ligase complex. NIK can escape from ubiquitination and subsequent degradation resulting in accumulation in the cytosol (Sas et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
15084608	Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation Harhaj, EW, Sun, SC, Zhang, M, Liao, G	J. Biol. Chem.	2004
18997794	Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK Mahoney, DJ, Wang, Y, Shiba, T, Mak, TW, Yeh, WC, Cheng, G, Dempsey, PW, He, J, Cheung, HH, Korneluk, RG, Yang, X, Zarnegar, BJ	Nat. Immunol.	2008