Protesomal degradation of K48polyUb-TRAF3

Stable Identifier
R-HSA-5668481
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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K48-linked ubiquitination of TRAF3 further leads to its proteasome-dependent degradation. The resultant degradation of TRAF3 releases NIK from the cIAPs ubiquitin-ligase complex. NIK can escape from ubiquitination and subsequent degradation resulting in accumulation in the cytosol (Sas et al. 2012).

Literature References
PubMed ID Title Journal Year
18997794 Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

Zarnegar, BJ, Wang, Y, Mahoney, DJ, Dempsey, PW, Cheung, HH, He, J, Shiba, T, Yang, X, Yeh, WC, Mak, TW, Korneluk, RG, Cheng, G

Nat. Immunol. 2008
15084608 Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation

Liao, G, Zhang, M, Harhaj, EW, Sun, SC

J. Biol. Chem. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created