2xTNFR2 binds TNFA trimer:TNFR2

Stable Identifier
R-HSA-5668467
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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TNF receptor-associated factor 2 (TNFR2) undergoes trimerization upon binding of transmembrane bound TNFA (tmTNFA) trimers, which leads to recruitment of TRAF2 to the intracellular TRAF-binding motif of TNFR2.
Literature References
PubMed ID Title Journal Year
21081755 Solution of the structure of the TNF-TNFR2 complex

Nakagawa, S, Tsunoda, S, Tsutsumi, Y, Yoshikawa, M, Yamagata, Y, Yoshioka, Y, Nakamura, T, Mukai, Y

Sci Signal 2010
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