2xTNFR2 binds TNFA trimer:TNFR2

Stable Identifier
R-HSA-5668467
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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TNF receptor-associated factor 2 (TNFR2) undergoes trimerization upon binding of transmembrane bound TNFA (tmTNFA) trimers, which leads to recruitment of TRAF2 to the intracellular TRAF-binding motif of TNFR2.

Literature References
PubMed ID Title Journal Year
21081755 Solution of the structure of the TNF-TNFR2 complex

Mukai, Y, Nakamura, T, Yoshikawa, M, Yoshioka, Y, Tsunoda, S, Nakagawa, S, Yamagata, Y, Tsutsumi, Y

Sci Signal 2010
Participants
Participant Of
Orthologous Events
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