2xTNFR2 binds TNFA trimer:TNFR2

Stable Identifier
R-HSA-5668467
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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2xTNFR2 binds TNFA trimer:TNFR2
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TNF receptor-associated factor 2 (TNFR2) undergoes trimerization upon binding of transmembrane bound TNFA (tmTNFA) trimers, which leads to recruitment of TRAF2 to the intracellular TRAF-binding motif of TNFR2.

Literature References
PubMed ID Title Journal Year
21081755 Solution of the structure of the TNF-TNFR2 complex

Mukai, Y, Nakamura, T, Yoshikawa, M, Yoshioka, Y, Tsunoda, S, Nakagawa, S, Yamagata, Y, Tsutsumi, Y

Sci Signal 2010
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
2xTNFR2 binds TNFA trimer:TNFR2 (Bos taurus)
2xTNFR2 binds TNFA trimer:TNFR2 (Canis familiaris)
2xTNFR2 binds TNFA trimer:TNFR2 (Mus musculus)
2xTNFR2 binds TNFA trimer:TNFR2 (Rattus norvegicus)
2xTNFR2 binds TNFA trimer:TNFR2 (Sus scrofa)
Authored
Garapati, P V  (2015-01-26)
Reviewed
Ware, CF  (2015-05-12)
Virgen-Slane, R  (2015-05-12)
Rajput, A  (2015-05-12)
Created
Garapati, P V  (2015-01-26)