cIAP1,2 targets NIK for ubiquitination and degradation under unstimulated conditions but redirects its destructive action towards TRAF3 in response to receptor signals. K63polyUb-cIAP1,2 catalyses K48-linked polyubiquitination of TRAF3 leading to signal-induced TARF3 degradation.
Vallabhapurapu, S, Matsuzawa, A, Zhang, W, Tseng, PH, Keats, JJ, Wang, H, Vignali, DA, Bergsagel, PL, Karin, M
Zarnegar, BJ, Wang, Y, Mahoney, DJ, Dempsey, PW, Cheung, HH, He, J, Shiba, T, Yang, X, Yeh, WC, Mak, TW, Korneluk, RG, Cheng, G
Matsuzawa, A, Tseng, PH, Vallabhapurapu, S, Luo, JL, Zhang, W, Wang, H, Vignali, DA, Gallagher, E, Karin, M
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