Reactome | K63polyUb-cIAP1,2 ubiquitinates TRAF3

K63polyUb-cIAP1,2 ubiquitinates TRAF3

Stable Identifier

R-HSA-5668454

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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cIAP1,2 targets NIK for ubiquitination and degradation under unstimulated conditions but redirects its destructive action towards TRAF3 in response to receptor signals. K63polyUb-cIAP1,2 catalyses K48-linked polyubiquitination of TRAF3 leading to signal-induced TARF3 degradation.

Literature References

PubMed ID	Title	Journal	Year
18997792	Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling Vallabhapurapu, S, Matsuzawa, A, Zhang, W, Tseng, PH, Keats, JJ, Wang, H, Vignali, DA, Bergsagel, PL, Karin, M	Nat. Immunol.	2008
18997794	Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK Zarnegar, BJ, Wang, Y, Mahoney, DJ, Dempsey, PW, Cheung, HH, He, J, Shiba, T, Yang, X, Yeh, WC, Mak, TW, Korneluk, RG, Cheng, G	Nat. Immunol.	2008
18635759	Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex Matsuzawa, A, Tseng, PH, Vallabhapurapu, S, Luo, JL, Zhang, W, Wang, H, Vignali, DA, Gallagher, E, Karin, M	Science	2008