K63polyUb-cIAP1,2 ubiquitinates TRAF3

Stable Identifier
R-HSA-5668454
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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cIAP1,2 targets NIK for ubiquitination and degradation under unstimulated conditions but redirects its destructive action towards TRAF3 in response to receptor signals. K63polyUb-cIAP1,2 catalyses K48-linked polyubiquitination of TRAF3 leading to signal-induced TARF3 degradation.

Literature References
PubMed ID Title Journal Year
18997792 Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

Vallabhapurapu, S, Matsuzawa, A, Zhang, W, Tseng, PH, Keats, JJ, Wang, H, Vignali, DA, Bergsagel, PL, Karin, M

Nat. Immunol. 2008
18997794 Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

Zarnegar, BJ, Wang, Y, Mahoney, DJ, Dempsey, PW, Cheung, HH, He, J, Shiba, T, Yang, X, Yeh, WC, Mak, TW, Korneluk, RG, Cheng, G

Nat. Immunol. 2008
18635759 Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

Matsuzawa, A, Tseng, PH, Vallabhapurapu, S, Luo, JL, Zhang, W, Wang, H, Vignali, DA, Gallagher, E, Karin, M

Science 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created