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cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
Stable Identifier
R-HSA-5668435
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Homo sapiens)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Homo sapiens)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
TRAF3 binds BAFFR:BAFF (Homo sapiens)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
TRAFs bind RANK:RANKL (Homo sapiens)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
TRAF3:NIK binds TRAF2:cIAP1/2 (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Homo sapiens)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Homo sapiens)
Participants
components
TRAF2:cIAP1,2 [cytosol]
(Homo sapiens)
TRAF3:NIK [cytosol]
(Homo sapiens)
Participates
as an input of
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)
TRAFs bind RANK:RANKL (Homo sapiens)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Homo sapiens)
TRAF3 binds BAFFR:BAFF (Homo sapiens)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Homo sapiens)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Homo sapiens)
as an output of
TRAF3:NIK binds TRAF2:cIAP1/2 (Homo sapiens)
as a component of
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Homo sapiens)
Inferred To
cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
(Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
(Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
(Danio rerio)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
(Gallus gallus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
(Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
(Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
(Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
(Xenopus tropicalis)
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