Tumor necrosis factor receptor 2 (TNFR2) signalling starts with recruitment of the adaptor protein TNF receptor-associated factor 2 (TRAF2) to the intracellular TRAF-binding motif and consequently to indirect recruitment of the TRAF2 associated proteins cellular inhibitors of apoptosis 1 and 2 (cIAP1 and cIAP2), along with a complex of TRAF3 and NF-kB-inducing kinase (NIK) which already interact with TRAF2 in unstimulated cells (Song & Donner. 1994, Rothe et al. 1995, Rothe et al. 1994). In resting cells usually NIK is targeted for ubiquitination and proteasomal degradation however in stimulated cells NIK escapes the ubiquitination by the cIAP1,2:TRAF2::TRAF3 complex due to rapid degradation of TRAF3.
Song, HY, Donner, DB
Rothe, M, Takeuchi, M, Goeddel, DV
Vaux, DL, Wong, WW, Day, CL, Davidson, AJ, Feltham, R, Pantaki, D, Silke, J, Walczak, H, Lee, EF, Vince, JE, Callus, BA, Carter, H, Gentle, IE, Schmukle, AC, Cordier, SM, Mace, PD
Ugarte, L, Cabal-Hierro, L, Artime, N, Lazo, PS, RodrÃguez, M, Prado, MA, Iglesias, J
Sarma, V, Rothe, M, Dixit, VM, Goeddel, DV
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