Reactome | TNFA binds TNFR2

TNFA binds TNFR2

Stable Identifier

R-HSA-5668404

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Tumor necrosis factor alpha (TNFA) exists in two biologically active forms, a transmembrane TNF-alpha (tmTNFA) and secretory TNF-alpha (sTNFA). tmTNFA is expressed as a functional 26kDa homotrimer transmembrane protein, which can be cleaved by a metalloproteinase TNFA-converting enzyme (TACE or ADAM17) to release the extracellular C-terminal portion with 17kDa, sTNFA. Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B or hereafter referred as TNFR2) preferentially binds with membrane integrated TNFA (Grell et al. 1995) and can activate the noncanonical NF-kB pathway (Rauert et al. 2010) as well as canonical NF-kB pathway (Marchetti et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
8521496	The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor Kollias, G, Lesslauer, W, Douni, E, Grell, M, Scheurich, P, Pfizenmaier, K, Löhden, M, Maxeiner, B, Clauss, M, Georgopoulos, S, Wajant, H	Cell	1995
9247583	Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria Redard, M, Burger, D, Juillard, P, De Kesel, T, Decoster, E, Grau, GE, Bluethmann, H, Buurman, WA, Moore, MW, Giroud, C, Monso-Hinard, C, Lucas, R, Fiers, W, Dayer, JM, Donati, Y	Eur. J. Immunol.	1997