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TNFRSF18 [plasma membrane]
Stable Identifier
R-HSA-5667163
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GITR, Tumor necrosis factor receptor superfamily member 18, TNR18_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) (Homo sapiens)
TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)
TNFRSF18 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
TNFs bind their physiological receptors (Homo sapiens)
TNFSF18 binds TNFRSF18 (Homo sapiens)
TNFRSF18 [plasma membrane] (Homo sapiens)
TNFSF18:TNFRSF18 [plasma membrane] (Homo sapiens)
TNFRSF18 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y5U5 TNFRSF18
Gene Names
TNFRSF18, AITR, GITR, UNQ319/PRO364
Chain
signal peptide:1-25, chain:26-241
Reference Genes
BioGPS Gene:8784 TNFRSF18
COSMIC (genes):TNFRSF18 TNFRSF18
CTD Gene:8784 TNFRSF18
dbSNP Gene:8784 TNFRSF18
ENSEMBL:ENSG00000186891 TNFRSF18
HGNC:11914 TNFRSF18
KEGG:hsa:8784 TNFRSF18
Monarch:8784 TNFRSF18
NCBI Gene:8784 TNFRSF18
OMIM:603905 TNFRSF18
UCSC:Q9Y5U5 TNFRSF18
Reference Transcript
RefSeq:NM_148901.1 TNFRSF18
RefSeq:NM_004195.2 TNFRSF18
RefSeq:NM_148902.1 TNFRSF18
Other Identifiers
11736692_a_at
16680075
223851_PM_s_at
223851_s_at
224553_PM_s_at
224553_s_at
2391151
2391152
2391153
2391155
2391156
2391157
2391159
2391160
2391161
71144_at
7911403
8784
A_24_P411121
GE61212
GO:0002687
GO:0005031
GO:0005515
GO:0005576
GO:0005886
GO:0006915
GO:0007165
GO:0009897
GO:0012501
GO:0016020
GO:0033209
GO:0042531
GO:0043066
GO:0045785
GO:0060089
HMNXSV003007144
ILMN_1743100
ILMN_2349633
PH_hs_0012309
TC01002085.hg
g4378799_3p_a_at
g7542578_3p_at
g7542578_3p_x_at
Participates
as a component of
TNFSF18:TNFRSF18 [plasma membrane] (Homo sapiens)
as an input of
TNFSF18 binds TNFRSF18 (Homo sapiens)
as an output of
TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)
Inferred To
TNFRSF18 [plasma membrane]
(Bos taurus)
TNFRSF18 [plasma membrane]
(Canis familiaris)
TNFRSF18 [plasma membrane]
(Gallus gallus)
TNFRSF18 [plasma membrane]
(Sus scrofa)
Tnfrsf18 [plasma membrane]
(Mus musculus)
Tnfrsf18 [plasma membrane]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
1890
ENSEMBL
ENSP00000368567
,
ENST00000379265
,
ENST00000379268
,
ENSP00000328207
,
ENST00000328596
,
ENSP00000368570
OpenTargets
ENSG00000186891
HPA
ENSG00000186891-TNFRSF18
PRO
Q9Y5U5
Pharos - Targets
Q9Y5U5
GlyGen
Q9Y5U5
PDB
7KHD
,
7LAW
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UNG2 TNFSF18
1
TNFSF18 [plasma membrane]
(R-HSA-5667147)
0.623
2
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