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LTA [plasma membrane]
Stable Identifier
R-HSA-5667153
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TNF-beta, TNFB, Lymphotoxin-alpha, TNFB_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LA,TNFSF14 binds LTBR (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
TNFs bind their physiological receptors (Homo sapiens)
LTA trimer binds TNFRSF1A,1B,14 (Homo sapiens)
LTA trimer [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA trimer:TNFRSF1A,1B,14 [plasma membrane] (Homo sapiens)
LTA trimer [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01374 LTA
Gene Names
LTA, TNFB, TNFSF1
Chain
signal peptide:1-34, chain:35-205
Reference Genes
BioGPS Gene:4049 LTA
COSMIC (genes):LTA LTA
CTD Gene:4049 LTA
dbSNP Gene:4049 LTA
ENSEMBL:ENSG00000226979 LTA
ENSEMBL_homo_sapiens_GENE:ENSG00000226979.9 LTA
ENSEMBL_homo_sapiens_GENE:ENSG00000230279.8 LTA
ENSEMBL_homo_sapiens_GENE:ENSG00000231408.8 LTA
HGNC:6709 LTA
KEGG Gene (Homo sapiens):4049 LTA
Monarch:4049 LTA
NCBI Gene:4049 LTA
OMIM:153440 LTA
Reference Transcript
RefSeq:XM_011514616.2 LTA
RefSeq:NM_001159740.2 LTA
RefSeq:XM_011514615.2 LTA
RefSeq:NM_000595.3 LTA
RefSeq:XM_011514618.1 LTA
RefSeq:XM_011514617.2 LTA
Other Identifiers
11730537_a_at
11749403_x_at
17006649
17027784
17030610
17033327
17035408
17038107
17040702
206975_PM_at
206975_at
258_at
2902408
2902409
2902410
2902411
2902413
2902414
2902415
36296_at
4049
8118137
8177976
8179258
A_14_P107480
A_14_P200177
A_23_P156683
GE57053
GO:0001666
GO:0002376
GO:0002876
GO:0002925
GO:0005102
GO:0005125
GO:0005164
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006915
GO:0006954
GO:0006955
GO:0006959
GO:0007154
GO:0007165
GO:0007267
GO:0007584
GO:0009410
GO:0012501
GO:0016020
GO:0023052
GO:0030154
GO:0032496
GO:0032729
GO:0043065
GO:0048018
GO:0048147
GO:0048535
GO:0048856
GO:0050830
GO:0060252
GO:0098542
GO:0098772
HMNXSV003032264
ILMN_1795464
M16441_cds1_at
PH_hs_0000003
TC06000370.hg
TC06002713.hg
TC6_cox_hap2000066.hg
TC6_dbb_hap3000057.hg
TC6_mann_hap4000058.hg
TC6_mcf_hap5000052.hg
TC6_qbl_hap6000057.hg
TC6_ssto_hap7000053.hg
g6806892_3p_at
Participates
as a component of
LTA trimer [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
Inferred To
LTA [plasma membrane]
(Bos taurus)
LTA [plasma membrane]
(Canis familiaris)
LTA [plasma membrane]
(Danio rerio)
LTA [plasma membrane]
(Sus scrofa)
lta [plasma membrane]
(Xenopus tropicalis)
Lta [plasma membrane]
(Mus musculus)
Lta [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_011512917.1
,
NP_000586.2
,
NP_001153212.1
,
XP_011512920.1
,
XP_011512918.1
,
XP_011512919.1
OpenTargets
ENSG00000226979
HPA
ENSG00000226979-LTA
ZINC - Substances
TNFB_HUMAN
GeneCards
P01374
ZINC target
P01374
Ensembl
ENSP00000413450
,
ENSG00000230279
,
ENSG00000231408
,
ENST00000436519
,
ENST00000454783
,
ENSP00000395976
,
ENST00000454550
,
ENSP00000412555
,
ENSG00000226979
,
ENST00000418386
,
ENST00000412851
,
ENST00000426845
,
ENSP00000416509
,
ENSP00000403495
,
ENSP00000402413
PRO
P01374
Pharos - Targets
P01374
ZINC - Predictions - Purchasable
TNFB_HUMAN
PDB
4MXW
,
1TNR
,
4MXV
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2
2
SLC30A2 [endosome membrane]
(R-HSA-435363)
SLC30A2 [synaptic vesicle membrane]
(R-HSA-4084714)
0.556
5
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