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LTB [plasma membrane]
Stable Identifier
R-HSA-5667150
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Lymphotoxin-beta, TNFC_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LA,TNFSF14 binds LTBR (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
lymphotoxin (LA) [plasma membrane] (Homo sapiens)
LTA1B2 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
LTB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q06643 LTB
Gene Names
LTB, TNFC, TNFSF3
Chain
chain:1-244
Reference Genes
BioGPS Gene:4050 LTB
COSMIC (genes):LTB LTB
CTD Gene:4050 LTB
dbSNP Gene:4050 LTB
ENSEMBL:ENSG00000227507 LTB
ENSEMBL_homo_sapiens_GENE:ENSG00000204487.8 LTB
ENSEMBL_homo_sapiens_GENE:ENSG00000206437.10 LTB
ENSEMBL_homo_sapiens_GENE:ENSG00000223448.7 LTB
ENSEMBL_homo_sapiens_GENE:ENSG00000227507.3 LTB
ENSEMBL_homo_sapiens_GENE:ENSG00000231314.7 LTB
ENSEMBL_homo_sapiens_GENE:ENSG00000236237.7 LTB
ENSEMBL_homo_sapiens_GENE:ENSG00000236925.7 LTB
ENSEMBL_homo_sapiens_GENE:ENSG00000238114.7 LTB
HGNC:6711 LTB
KEGG Gene (Homo sapiens):4050 LTB
Monarch:4050 LTB
NCBI Gene:4050 LTB
OMIM:600978 LTB
UCSC:Q06643 LTB
Reference Transcript
RefSeq:NM_009588.1 LTB
RefSeq:NM_002341.1 LTB
Other Identifiers
11739657_a_at
11739658_a_at
17026762
17029082
17031867
17034339
17036587
17039380
17041863
207339_PM_s_at
207339_s_at
2949119
2949120
2949121
2949126
2949128
2949130
2949131
4050
40729_s_at
8124950
8178512
8179768
A_23_P93348
A_33_P3248265
GE61199
GO:0002376
GO:0005102
GO:0005125
GO:0005164
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005886
GO:0006955
GO:0007154
GO:0007165
GO:0007267
GO:0010467
GO:0012501
GO:0016020
GO:0023052
GO:0032735
GO:0043123
GO:0043588
GO:0048018
GO:0048535
GO:0048856
GO:0098772
GO:2001238
HMNXSV003002080
ILMN_2376204
ILMN_2376205
PH_hs_0024260
TC06001530.hg
TC06003591.hg
TC06003592.hg
TC6_apd_hap1000081.hg
TC6_cox_hap2000159.hg
TC6_dbb_hap3000148.hg
TC6_mann_hap4000136.hg
TC6_mcf_hap5000136.hg
TC6_qbl_hap6000151.hg
TC6_ssto_hap7000131.hg
U89922_s_at
g4505034_3p_a_at
Participates
as a component of
LTA1B2 [plasma membrane] (Homo sapiens)
LTA2B1 [plasma membrane] (Homo sapiens)
Inferred To
TNLG1C [plasma membrane]
(Canis familiaris)
NCR3 [plasma membrane]
(Bos taurus)
ltb [plasma membrane]
(Xenopus tropicalis)
Ltb [plasma membrane]
(Mus musculus)
Ltb [plasma membrane]
(Rattus norvegicus)
LTB [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_002332.1
,
NP_033666.1
OpenTargets
ENSG00000227507
GeneCards
Q06643
HPA
ENSG00000227507-LTB
Ensembl
ENSG00000236237
,
ENST00000446745
,
ENSP00000372985
,
ENST00000383493
,
ENST00000376117
,
ENSP00000395102
,
ENSG00000204487
,
ENSP00000365285
,
ENST00000457552
,
ENST00000420402
,
ENSP00000410481
,
ENST00000444479
,
ENSP00000404014
,
ENSP00000404450
,
ENST00000421268
,
ENSG00000238114
,
ENSG00000236925
,
ENSG00000223448
,
ENSG00000227507
,
ENSG00000206437
,
ENSP00000393693
,
ENST00000429299
,
ENSG00000231314
,
ENSP00000398741
,
ENSP00000416113
,
ENST00000456113
PRO
Q06643
Pharos - Targets
Q06643
PDB
4MXW
HMDB Protein
HMDBP02942
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