PARK2 K63-Ubiquitinates SNCAIP

Stable Identifier
R-HSA-5667111
Type
Reaction [omitted]
Species
Homo sapiens
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SNCAIP is ubiquitinated by several different E3 ubiquitin-ligases, including Parkin (PARK2). PARK2 overexpression with SNCAIP in cell culture leads to the formation of protein aggregates (Chung et al. 2001). PARK2 preferentially mediates the addition of lysine-63 (K63)-linked polyubiquitination of SNCAIP (Lim et al. 2005). This leads to SNCAIP degradation only at an unusually high PARK2 to SNCAIP ratio (Lim et al. 2005). K63-linked ubiquitination may be a signal that leads to the degradation of inclusions by autophagy when the ubiquitin-proteasome system is dysfunctional (Lim et al. 2005, Tan et al. 2008).

Literature References
PubMed ID Title Journal Year
11590439 Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

Chung, KK, Zhang, Y, Lim, KL, Tanaka, Y, Huang, H, Gao, J, Ross, CA, Dawson, VL, Dawson, TM

Nat. Med. 2001
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Catalyst Activity
Title
ubiquitin-protein transferase activity of PARK2:SNCAIP [cytosol]
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