Reactome | CD27 [plasma membrane]

CD27 [plasma membrane]

Stable Identifier

R-HSA-5666994

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD27 antigen, CD27_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8TBA6 GOLGA5

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External Reference Information

External Reference

UniProt:P26842 CD27

Gene Names

CD27, TNFRSF7

Chain

signal peptide:1-19, chain:20-260

Reference Genes

BioGPS Gene:939 CD27

COSMIC (genes):CD27 CD27

CTD Gene:939 CD27

dbSNP Gene:939 CD27

ENSEMBL:ENSG00000139193 CD27

ENSEMBL_homo_sapiens_GENE:ENSG00000139193.4 CD27

HGNC:11922 CD27

KEGG Gene (Homo sapiens):939 CD27

Monarch:939 CD27

NCBI Gene:939 CD27

OMIM:186711 CD27

UCSC:P26842 CD27

Reference Transcript

RefSeq:NM_001242.4 CD27

Other Identifiers

11725481_a_at

16747261

206150_PM_at

206150_at

3402507

3402508

3402509

3402511

3402513

3402514

3402516

3402517

3402518

3402519

3402521

38578_at

7953333

939

A_14_P139106

A_14_P200329

A_23_P48088

GE61298

GO:0002376

GO:0004888

GO:0005515

GO:0005576

GO:0005886

GO:0006915

GO:0007155

GO:0007166

GO:0009897

GO:0009986

GO:0012501

GO:0016020

GO:0016064

GO:0023052

GO:0030154

GO:0043027

GO:0043066

GO:0045471

GO:0045579

GO:0045582

GO:0046330

GO:0048856

GO:0060089

GO:0070233

GO:0097191

GO:0098772

GO:1901224

HMNXSV003031034

ILMN_1688959

M63928_at

PH_hs_0017208

TC12000080.hg

g4507586_3p_at

Participates

as a component of

CD27:CD70 homotrimer [plasma membrane] (Homo sapiens)

as an input of

CD70 binds CD27 (Homo sapiens)

Inferred To

Cd27 [plasma membrane] (Mus musculus)

CD27 [plasma membrane] (Bos taurus)

CD27 [plasma membrane] (Canis familiaris)

CD27 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001233.1

Guide to Pharmacology - Targets

1876

OpenTargets

ENSG00000139193

HPA

ENSG00000139193-CD27

GeneCards

P26842

Ensembl

ENSG00000139193, ENSP00000266557, ENST00000266557

PRO

P26842

Pharos - Targets

P26842

Orphanet

22186

PDB

5TLJ, 5TL5, 7KX0, 5TLK, 8DS5

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15304 SIVA			0.635	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.556	3
UniProt:Q99828 CIB1			0.556	7
UniProt:P0DTD1-PRO_0000449624 REP			0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.547	3
UniProt:Q8TBA6 GOLGA5	2	GOLGA5 [transport vesicle] (R-HSA-8847517) GOLGA5 [Golgi membrane] (R-HSA-8847514)	0.527	3
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.527	2
UniProt:O60503 ADCY9	1	ADCY9 [plasma membrane] (R-HSA-379055)	0.527	2
UniProt:O60779 SLC19A2	1	SLC19A2 [plasma membrane] (R-HSA-199636)	0.527	2
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	2
UniProt:Q9H1U9 S2551			0.527	3
UniProt:A6NFQ2 TCAF2			0.527	3
UniProt:Q5HYA8 TMEM67	1	TMEM67 [ciliary membrane] (R-HSA-5626667)	0.527	3
UniProt:Q02383 SEMG2			0.527	2
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.527	2
UniProt:P04279 SEMG1	2	SEMG1 [extracellular region] (R-HSA-977100) hC239-SEMG1 [extracellular region] (R-HSA-6810688)	0.527	2

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