RHOA:GTP:RTKN binds TAX1BP3

Stable Identifier
R-HSA-5666216
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The PDZ domain of TAX1BP3 (TIP-1) binds the C-terminus of RTKN (rhotekin) associated with activated RHOA (RHOA:GTP). Binding of TAX1BP3 to the RHOA:GTP:RTKN complex stimulates SRF-mediated transcription through an unknown mechanism (Reynaud et al. 2000).

Literature References
PubMed ID Title Journal Year
10940294 The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element

Reynaud, C, Fabre, S, Jalinot, P

J. Biol. Chem. 2000
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