RTKN binds RHOA, RHOC or RHOB

Stable Identifier
R-HSA-5666178
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Rhotekin (RTKN) has the evolutionarily conserved RHO GTPase binding domain at its N-terminus and strongly binds to RHOA and RHOC. RTKN also associates with RHOB with a lower affinity and does not bind RAC1 or CDC42 (Reid et al. 1996). Binding of RTKN may inhibit the GTPase activity of RHO GTPases (Fu et al. 2000).
Literature References
PubMed ID Title Journal Year
8662891 Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain

Madaule, P, Fujisawa, K, Narumiya, S, Furuyashiki, T, Watanabe, G, Reid, T, Watanabe, N, Ishizaki, T, Morii, N

J. Biol. Chem. 1996
10873388 Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286

Yu, L, Zhang, J, Fu, Q, Zhao, S, Zhang, H, Liu, Q

Genomics 2000
Participants
Participates
Inferred From
Authored
Created
Cite Us!