Reactome | RTKN binds RHOA, RHOC or RHOB

RTKN binds RHOA, RHOC or RHOB

Stable Identifier

R-HSA-5666178

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Rhotekin (RTKN) has the evolutionarily conserved RHO GTPase binding domain at its N-terminus and strongly binds to RHOA and RHOC. RTKN also associates with RHOB with a lower affinity and does not bind RAC1 or CDC42 (Reid et al. 1996). Binding of RTKN may inhibit the GTPase activity of RHO GTPases (Fu et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
8662891	Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain Madaule, P, Fujisawa, K, Narumiya, S, Furuyashiki, T, Watanabe, G, Reid, T, Watanabe, N, Ishizaki, T, Morii, N	J. Biol. Chem.	1996
10873388	Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286 Yu, L, Zhang, J, Fu, Q, Zhao, S, Zhang, H, Liu, Q	Genomics	2000