AURKB phosphorylates DIAPH2-2 at kinetochores

Stable Identifier
R-HSA-5666160
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aurora kinase B (AURKB), which is part of the kinetochore, phosphorylates DIAPH2-2 (DIA-12C, mDia3) on serine residue S196 in the FH3 (DID) domain and probably on several other residues in the FH3 and FH2 domains. AURKB-mediated phosphorylation of DIAPH2-2 is necessary for the regulation of microtubule binding to kinetochores by the CDC42:GTP:DIAPH2-2 complex (Cheng et al. 2011).

Literature References
PubMed ID Title Journal Year
21397845 Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment

Cheng, L, Zhang, J, Ahmad, S, Rozier, L, Yu, H, Deng, H, Mao, Y

Dev. Cell 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created