Reactome | AURKB phosphorylates DIAPH2-2 at kinetochores

AURKB phosphorylates DIAPH2-2 at kinetochores

Stable Identifier

R-HSA-5666160

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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AURKB phosphorylates DIAPH2-2 at kinetochores

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Aurora kinase B (AURKB), which is part of the kinetochore, phosphorylates DIAPH2-2 (DIA-12C, mDia3) on serine residue S196 in the FH3 (DID) domain and probably on several other residues in the FH3 and FH2 domains. AURKB-mediated phosphorylation of DIAPH2-2 is necessary for the regulation of microtubule binding to kinetochores by the CDC42:GTP:DIAPH2-2 complex (Cheng et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21397845	Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment Cheng, L, Zhang, J, Ahmad, S, Rozier, L, Yu, H, Deng, H, Mao, Y	Dev. Cell	2011