RHOD:GTP recruits DAIPH2-3 to endosomes

Stable Identifier
R-HSA-5666088
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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RHOD:GTP recruits DAIPH2-3 to endosomes
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Activated RHOD (RHOD:GTP) binds DIAPH2 transcription isoform DIAPH2-3 (DIAPH2C) and recruits it to endosomes. RHOD and DIAPH2 regulate endosome motility through SRC-dependent regulation of actin dynamics (Gasman et al. 2003).
Literature References
PubMed ID Title Journal Year
12577064 RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase

Kalaidzidis, Y, Gasman, S, Zerial, M

Nat. Cell Biol. 2003
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Orthologous Events
RHOD:GTP recruits DAIPH2-3 to endosomes (Bos taurus)
RHOD:GTP recruits DAIPH2-3 to endosomes (Caenorhabditis elegans)
RHOD:GTP recruits DAIPH2-3 to endosomes (Canis familiaris)
RHOD:GTP recruits DAIPH2-3 to endosomes (Drosophila melanogaster)
RHOD:GTP recruits DAIPH2-3 to endosomes (Mus musculus)
RHOD:GTP recruits DAIPH2-3 to endosomes (Rattus norvegicus)
RHOD:GTP recruits DAIPH2-3 to endosomes (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-21)
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