SCAI binds SRF:MKL1

Stable Identifier
R-HSA-5666008
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SCAI binds SRF:MKL1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SCAI forms a ternary complex with MKL1 and SRF, inhibiting the transcriptional activity of the SRF:MKL1 complex. SCAI negatively regulates cancer cell invasion facilitated by the SRF:MKL1-mediated transcription downstream of RHOA and DIAPH1, and therefore acts as a tumor suppressor (Brandt et al. 2009).

Literature References
PubMed ID Title Journal Year
19350017 SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin

Brandt, DT, Baarlink, C, Kitzing, TM, Kremmer, E, Ivaska, J, Nollau, P, Grosse, R

Nat. Cell Biol. 2009
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
SCAI binds SRF:MKL1 (Bos taurus)
SCAI binds SRF:MKL1 (Canis familiaris)
SCAI binds SRF:MKL1 (Danio rerio)
SCAI binds SRF:MKL1 (Drosophila melanogaster)
SCAI binds SRF:MKL1 (Mus musculus)
SCAI binds SRF:MKL1 (Rattus norvegicus)
SCAI binds SRF:MKL1 (Sus scrofa)
SCAI binds SRF:MKL1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-21)
Cite Us!