SCAI binds SRF:MKL1

Stable Identifier
R-HSA-5666008
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SCAI binds SRF:MKL1
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SCAI forms a ternary complex with MKL1 and SRF, inhibiting the transcriptional activity of the SRF:MKL1 complex. SCAI negatively regulates cancer cell invasion facilitated by the SRF:MKL1-mediated transcription downstream of RHOA and DIAPH1, and therefore acts as a tumor suppressor (Brandt et al. 2009).
Literature References
PubMed ID Title Journal Year
19350017 SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin

Kitzing, TM, Grosse, R, Brandt, DT, Ivaska, J, Nollau, P, Kremmer, E, Baarlink, C

Nat. Cell Biol. 2009
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Orthologous Events
SCAI binds SRF:MKL1 (Bos taurus)
SCAI binds SRF:MKL1 (Canis familiaris)
SCAI binds SRF:MKL1 (Drosophila melanogaster)
SCAI binds SRF:MKL1 (Gallus gallus)
SCAI binds SRF:MKL1 (Mus musculus)
SCAI binds SRF:MKL1 (Rattus norvegicus)
SCAI binds SRF:MKL1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-21)
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