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MKL1 translocates from cytosol to the nucleus
Stable Identifier
R-HSA-5665999
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
MKL1 translocates from cytosol to the nucleus (Homo sapiens)
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The release of MKL1 (MAL) from nonpolymerized actin (G-actin), after profilin:G-actin complexes bind DIAPH1 and EVL (VASP) downstream of activated RHOA, enables MKL1 to translocate from the cytosol to the nucleus (Miralles et al. 2003).
Literature References
PubMed ID
Title
Journal
Year
12732141
Actin dynamics control SRF activity by regulation of its coactivator MAL
Posern, G
,
Treisman, R
,
Miralles, F
,
Zaromytidou, AI
Cell
2003
Participants
Input
MKL1 [cytosol]
(Homo sapiens)
Output
MKL1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RHO GTPases Activate Formins (Homo sapiens)
Orthologous Events
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MKL1 translocates from cytosol to the nucleus (Gallus gallus)
MKL1 translocates from cytosol to the nucleus (Mus musculus)
MKL1 translocates from cytosol to the nucleus (Rattus norvegicus)
MKL1 translocates from cytosol to the nucleus (Sus scrofa)
MKL1 translocates from cytosol to the nucleus (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2014-10-24)
Rivero Crespo, F (2014-12-26)
Created
Orlic-Milacic, M (2015-01-21)
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