FMNL3 binds activated (GTP-bound) RHOC. RHOC-mediated activation of FMNL3 promotes polarized cell migration which may be involved in cancer cell invasion (Vega et al. 2011). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL3 (Moriya et al. 2012).
Sagot, I, Moseley, JB, Poy, F, Eck, MJ, Goode, BL, Pellman, D, Xu, Y
Kühn, S, Geyer, M
Ridley, AJ, Vega, FM, Fruhwirth, G, Ng, T
Suzuki, T, Utsumi, T, Takamitsu, E, Matsunaga, Y, Kimoto, M, Moriya, K, Fukushige, D, Yamamoto, T, Kimoto, C
© 2023 Reactome
