FMNL3 binds RHOC:GTP

Stable Identifier
R-HSA-5665761
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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FMNL3 binds RHOC:GTP
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FMNL3 binds activated (GTP-bound) RHOC. RHOC-mediated activation of FMNL3 promotes polarized cell migration which may be involved in cancer cell invasion (Vega et al. 2011). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL3 (Moriya et al. 2012).

Literature References
PubMed ID Title Journal Year
24914801 Formins as effector proteins of Rho GTPases

Kühn, S, Geyer, M

Small GTPases 2014
15006353 Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture

Xu, Y, Moseley, JB, Sagot, I, Poy, F, Pellman, D, Goode, BL, Eck, MJ

Cell 2004
21576392 RhoA and RhoC have distinct roles in migration and invasion by acting through different targets

Vega, FM, Fruhwirth, G, Ng, T, Ridley, AJ

J. Cell Biol. 2011
22790947 Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3

Moriya, K, Yamamoto, T, Takamitsu, E, Matsunaga, Y, Kimoto, M, Fukushige, D, Kimoto, C, Suzuki, T, Utsumi, T

Biosci. Biotechnol. Biochem. 2012
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
FMNL3 binds RHOC:GTP (Bos taurus)
FMNL3 binds RHOC:GTP (Caenorhabditis elegans)
FMNL3 binds RHOC:GTP (Canis familiaris)
FMNL3 binds RHOC:GTP (Danio rerio)
FMNL3 binds RHOC:GTP (Drosophila melanogaster)
FMNL3 binds RHOC:GTP (Mus musculus)
FMNL3 binds RHOC:GTP (Rattus norvegicus)
FMNL3 binds RHOC:GTP (Sus scrofa)
FMNL3 binds RHOC:GTP (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-19)