FMNL3 binds activated (GTP-bound) RHOC. RHOC-mediated activation of FMNL3 promotes polarized cell migration which may be involved in cancer cell invasion (Vega et al. 2011). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL3 (Moriya et al. 2012).
Kühn, S, Geyer, M
Xu, Y, Moseley, JB, Sagot, I, Poy, F, Pellman, D, Goode, BL, Eck, MJ
Vega, FM, Fruhwirth, G, Ng, T, Ridley, AJ
Moriya, K, Yamamoto, T, Takamitsu, E, Matsunaga, Y, Kimoto, M, Fukushige, D, Kimoto, C, Suzuki, T, Utsumi, T
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