Reactome | FMNL3 binds RHOC:GTP

FMNL3 binds RHOC:GTP

Stable Identifier

R-HSA-5665761

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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FMNL3 binds activated (GTP-bound) RHOC. RHOC-mediated activation of FMNL3 promotes polarized cell migration which may be involved in cancer cell invasion (Vega et al. 2011). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL3 (Moriya et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
15006353	Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture Xu, Y, Moseley, JB, Sagot, I, Poy, F, Pellman, D, Goode, BL, Eck, MJ	Cell	2004
24914801	Formins as effector proteins of Rho GTPases Kühn, S, Geyer, M	Small GTPases	2014
21576392	RhoA and RhoC have distinct roles in migration and invasion by acting through different targets Vega, FM, Fruhwirth, G, Ng, T, Ridley, AJ	J. Cell Biol.	2011
22790947	Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3 Moriya, K, Yamamoto, T, Takamitsu, E, Matsunaga, Y, Kimoto, M, Fukushige, D, Kimoto, C, Suzuki, T, Utsumi, T	Biosci. Biotechnol. Biochem.	2012