FMNL3 binds activated (GTP-bound) RHOC. RHOC-mediated activation of FMNL3 promotes polarized cell migration which may be involved in cancer cell invasion (Vega et al. 2011). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL3 (Moriya et al. 2012).
Suzuki, T, Utsumi, T, Takamitsu, E, Matsunaga, Y, Kimoto, M, Moriya, K, Fukushige, D, Yamamoto, T, Kimoto, C
Sagot, I, Moseley, JB, Poy, F, Eck, MJ, Goode, BL, Pellman, D, Xu, Y
Ridley, AJ, Vega, FM, Fruhwirth, G, Ng, T
Kühn, S, Geyer, M
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