CDC42:GTP:FMNL2 binds Profilin:G-actin

Stable Identifier
R-HSA-5665751
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Once activated by binding to GTP-bound CDC42, FMNL2 interacts with actin bound profilin(s) and drives elongation but not nucleation of actin filaments (Block et al. 2012). The interaction between formins and profilins is achieved through the proline-rich FH1 domain of formins, while the interaction with actin is achieved through the FH2 domain of formins (Romero et al. 2004, Kovar et al. 2006, Kuhn and Geyer 2014).

Literature References
PubMed ID Title Journal Year
24914801 Formins as effector proteins of Rho GTPases

Kühn, S, Geyer, M

Small GTPases 2014
15507212 Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis

Romero, S, Le Clainche, C, Didry, D, Egile, C, Pantaloni, D, Carlier, MF

Cell 2004
22608513 FMNL2 drives actin-based protrusion and migration downstream of Cdc42

Block, J, Breitsprecher, D, Kühn, S, Winterhoff, M, Kage, F, Geffers, R, Duwe, P, Rohn, JL, Baum, B, Brakebusch, C, Geyer, M, Stradal, TE, Faix, J, Rottner, K

Curr. Biol. 2012
16439214 Control of the assembly of ATP- and ADP-actin by formins and profilin

Kovar, DR, Harris, ES, Mahaffy, R, Higgs, HN, Pollard, TD

Cell 2006
Participants
Participant Of
Orthologous Events
Authored
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