FMNL2 specifically interacts with the GTP-bound RHOC, which relieves FMNL2 autoinhibition and contributes to RHOC-mediated ameboid cell motility involved in cancer cell invasion (Kitzing et al. 2010). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL2 (Moriya et al. 2012).
Grosse, R, Copeland, JW, Kitzing, TM, Pertz, O, Wang, Y
Suzuki, T, Utsumi, T, Takamitsu, E, Matsunaga, Y, Kimoto, M, Moriya, K, Fukushige, D, Yamamoto, T, Kimoto, C
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