FMNL2 binds RHOC:GTP

Stable Identifier
R-HSA-5665748
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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FMNL2 binds RHOC:GTP
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FMNL2 specifically interacts with the GTP-bound RHOC, which relieves FMNL2 autoinhibition and contributes to RHOC-mediated ameboid cell motility involved in cancer cell invasion (Kitzing et al. 2010). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL2 (Moriya et al. 2012).
Literature References
PubMed ID Title Journal Year
20101212 Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC

Grosse, R, Copeland, JW, Kitzing, TM, Pertz, O, Wang, Y

Oncogene 2010
22790947 Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3

Suzuki, T, Utsumi, T, Takamitsu, E, Matsunaga, Y, Kimoto, M, Moriya, K, Fukushige, D, Yamamoto, T, Kimoto, C

Biosci. Biotechnol. Biochem. 2012
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Orthologous Events
FMNL2 binds RHOC:GTP (Bos taurus)
FMNL2 binds RHOC:GTP (Canis familiaris)
FMNL2 binds RHOC:GTP (Gallus gallus)
FMNL2 binds RHOC:GTP (Mus musculus)
FMNL2 binds RHOC:GTP (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-20)
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