FMNL2 specifically interacts with the GTP-bound RHOC, which relieves FMNL2 autoinhibition and contributes to RHOC-mediated ameboid cell motility involved in cancer cell invasion (Kitzing et al. 2010). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL2 (Moriya et al. 2012).
Moriya, K, Yamamoto, T, Takamitsu, E, Matsunaga, Y, Kimoto, M, Fukushige, D, Kimoto, C, Suzuki, T, Utsumi, T
Kitzing, TM, Wang, Y, Pertz, O, Copeland, JW, Grosse, R
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