RORA and EP300 bind the Carnitine O-palmitoyltransferase 1 (CPT1A) gene

Stable Identifier
R-HSA-5663264
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RORA and EP300 bind the Carnitine O-palmitoyltransferase 1 (CPT1A) gene
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As inferred from mouse homologs, RORA binds RRE DNA elements in the promoter of CPT1A and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase) to enhance transcription of CPT1A, which encodes Carnitine O-palmitoyltransferase 1, an enzyme required for uptake and beta oxidation of fatty acids by mitochondria.
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Input
Output
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as an event of
Inferred From
Rora, Ep300 bind Cpt1a gene (Mus musculus)
Authored
May, B  (2015-01-16)
Reviewed
Delaunay, F  (2012-01-28)
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2015-01-17)
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