NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors

Stable Identifier
R-HSA-5663245
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors
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NR1D1 (REV-ERBA) binds the promoter of the NPAS2 gene and recruits corepressors to repress transcription. Recruitment of repressors appears to depend on the binding of heme by NR1D1.

Literature References
PubMed ID Title Journal Year
20817722 Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene

Crumbley, C, Wang, Y, Kojetin, DJ, Burris, TP

J Biol Chem 2010
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Authored
May, B  (2015-01-16)
Reviewed
Delaunay, F  (2012-01-28)
Somers, J  (2021-01-23)
Created
May, B  (2015-01-17)
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