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FMNL1 [cytosol]
Stable Identifier
R-HSA-5663224
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Formin-like protein 1, FRL1, FRL, FRLalpha
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
FMNL1 binds CDC42:GTP (Homo sapiens)
CDC42:GTP:FMNL1 [plasma membrane] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 binds RAC1:GTP (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
RAC1:GTP:FMNL1 [plasma membrane] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
RAC1:GTP:FMNL1 binds profilin:G-actin (Homo sapiens)
RAC1:GTP:FMNL1 [plasma membrane] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
RAC1:GTP:FMNL1 [plasma membrane] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
RAC1:GTP:FMNL1 [plasma membrane] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
RAC1:GTP:FMNL1 [plasma membrane] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
RAC1:GTP:FMNL1 [plasma membrane] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
FMNL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95466 FMNL1
Gene Names
FMNL1, C17orf1, C17orf1B, FMNL, FRL1
Chain
initiator methionine:, chain:2-1100
Reference Genes
BioGPS Gene:752 FMNL1
COSMIC (genes):FMNL1 FMNL1
CTD Gene:752 FMNL1
dbSNP Gene:752 FMNL1
ENSEMBL:ENSG00000184922 FMNL1
HGNC:1212 FMNL1
KEGG:hsa:752 FMNL1
Monarch:752 FMNL1
NCBI Gene:752 FMNL1
OMIM:604656 FMNL1
UCSC:O95466 FMNL1
Reference Transcript
RefSeq:XM_006722063.3 FMNL1
RefSeq:XM_006722070.3 FMNL1
RefSeq:NM_005892.3 FMNL1
Other Identifiers
11727913_a_at
11763558_a_at
11763559_x_at
11763641_a_at
11763644_x_at
11763658_a_at
11763659_x_at
11763686_x_at
11763733_x_at
1569257_3p_at
1569257_PM_at
1569257_at
16834931
204789_PM_at
204789_at
37100_at
3723379
3723380
3723381
3723382
3723387
3723389
3723390
3723391
3723392
3723393
3723394
3723395
3723396
3723397
3723398
3723399
3723400
3723401
3723402
3723403
3723404
3723405
3723406
3723407
3723408
3723409
3723410
3723411
3723412
3723413
3723414
3723415
3723416
3723417
3723419
3723420
3723421
3723422
3723423
3723424
3723426
3723427
3723428
3723429
3723430
3723431
3723432
3723433
3723434
3723436
752
8007757
A_14_P130134
A_24_P390668
A_33_P3382303
GE55183
GO:0003674
GO:0003779
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005938
GO:0007010
GO:0008092
GO:0008360
GO:0016020
GO:0016043
GO:0016477
GO:0022604
GO:0030036
GO:0030866
GO:0031267
GO:0031410
GO:0032059
GO:0032794
GO:0042995
GO:0043226
GO:0045335
GO:0048870
GO:0051014
GO:0051015
GO:0070062
HMNXSV003023451
HMNXSV003024415
HMNXSV003051446
Hs2.438500.1.S1_3p_x_at
ILMN_1782748
PH_hs_0005602
TC17000582.hg
g5174400_3p_at
g5174400_3p_x_at
Participates
as a component of
FMNL1 [cytosol] (Homo sapiens)
Inferred To
FMNL1 [cytosol]
(Bos taurus)
FMNL1 [cytosol]
(Canis familiaris)
FMNL1 [cytosol]
(Gallus gallus)
FMNL1 [cytosol]
(Sus scrofa)
fozi-1 [cytosol]
(Caenorhabditis elegans)
fmnl1 [cytosol]
(Xenopus tropicalis)
Fmnl1 [cytosol]
(Mus musculus)
Fmnl1 [cytosol]
(Rattus norvegicus)
fmnl1a [cytosol]
(Danio rerio)
Frl [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_005883.2
,
XP_006722133.1
,
XP_006722126.1
ENSEMBL
ENST00000587489
,
ENST00000331495
,
ENSP00000465474
,
ENSP00000329219
OpenTargets
ENSG00000184922
HPA
ENSG00000184922-FMNL1
PRO
O95466
Pharos - Targets
O95466
GlyGen
O95466
PDB
4YDH
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75044 SRGAP2
1
SRGAP2 [cytosol]
(R-HSA-195131)
0.602
3
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