p-BMAL1:p-CLOCK,NPAS2 binds PER1 gene

Stable Identifier
R-HSA-5663174
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds E-boxes in the promoter of the PER1 gene and activates transcription of PER1. NPAS2 is predicted to act redundantly with CLOCK.

Literature References
PubMed ID Title Journal Year
9427249 Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei

Shearman, LP, Zylka, MJ, Weaver, DR, Kolakowski LF, Jr, Reppert, SM

Neuron 1997
9333243 Circadian oscillation of a mammalian homologue of the Drosophila period gene

Tei, H, Okamura, H, Shigeyoshi, Y, Fukuhara, C, Ozawa, R, Hirose, M, Sakaki, Y

Nature 1997
14750904 Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts

Miyazaki, K, Nagase, T, Mesaki, M, Narukawa, J, Ohara, O, Ishida, N

Biochem J 2004
17994337 Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways

Motzkus, D, Loumi, S, Cadenas, C, Vinson, C, Forssmann, WG, Maronde, E

Chronobiol Int 2007
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