p-BMAL1:p-CLOCK,NPAS2 binds CRY1 gene

Stable Identifier
R-HSA-5663120
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-BMAL1:p-CLOCK,NPAS2 binds CRY1 gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds an E-box in the promoter of the CRY1 gene and activates transcription of CRY1. NPAS2 is predicted to act redundantly with CLOCK.
Literature References
PubMed ID Title Journal Year
18317514 Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXRalpha-Regulated and CLOCK/BMAL1-Regulated Systems

Katayama, S, Inoue, I, Nakamura, K, Takahashi, S, Komoda, T

PPAR Res 2008
Participants
Input
Output
Participates
as an event of
Inferred From
p-Bmal1:p-Clock,Npas2 binds Cry1 gene (Mus musculus)
Authored
May, B  (2015-01-15)
Reviewed
Delaunay, F  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Albrecht, U  (2010-06-23)
Created
May, B  (2015-01-16)
Cite Us!