p-BMAL1:p-CLOCK,NPAS2 binds CRY1 gene

Stable Identifier
R-HSA-5663120
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds an E-box in the promoter of the CRY1 gene and activates transcription of CRY1. NPAS2 is predicted to act redundantly with CLOCK.

Literature References
PubMed ID Title Journal Year
18317514 Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXRalpha-Regulated and CLOCK/BMAL1-Regulated Systems

Nakamura, K, Inoue, I, Takahashi, S, Komoda, T, Katayama, S

PPAR Res 2008
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