p-BMAL1:p-CLOCK,NPAS2 binds PER2 gene

Stable Identifier
R-HSA-5663118
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-BMAL1:p-CLOCK,NPAS2 binds PER2 gene
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As inferred from mouse, the phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds a noncanonical E-box in the promoter of the PER2 gene and activates transcription of PER2. NPAS2 is predicted to act redundantly with CLOCK.
Literature References
PubMed ID Title Journal Year
18317514 Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXRalpha-Regulated and CLOCK/BMAL1-Regulated Systems

Katayama, S, Inoue, I, Nakamura, K, Takahashi, S, Komoda, T

PPAR Res 2008
9427249 Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei

Zylka, MJ, Reppert, SM, Kolakowski LF, Jr, Shearman, LP, Weaver, DR

Neuron 1997
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Inferred From
p-Bmal1:p-Clock,Npas2 binds Per2 gene (Mus musculus)
Authored
May, B  (2015-01-15)
Reviewed
Delaunay, F  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Albrecht, U  (2010-06-23)
Created
May, B  (2015-01-16)
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