MT3 binds copper

Stable Identifier
R-HSA-5663002
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MT3 binds copper
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The metallothionein MT3 is able to bind 12 copper(I) atoms when fully saturated (Roschitzki et al. 2002). Initially, 4 copper(I) atoms bind to each of the alpha and beta domains followed by the binding of 4 more copper(I) atoms. As inferred from the mouse homolog, MT3 exhibits a Cu-thionein character stronger than that of the MT1 and MT2 isoforms and it displays a high capacity to bind Cu+ provided that this occurs in a non-oxidative milieux.
Literature References
PubMed ID Title Journal Year
12072966 A distinct Cu(4)-thiolate cluster of human metallothionein-3 is located in the N-terminal domain

Vasák, M, Roschitzki, B

J. Biol. Inorg. Chem. 2002
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Inferred From
Mt3 binds copper (Mus musculus)
Authored
May, B  (2015-01-13)
Reviewed
Atrian, S  (2015-09-19)
Created
May, B  (2015-01-14)
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