Reactome | MT2A binds copper

MT2A binds copper

Stable Identifier

R-HSA-5662986

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The metallothionein MT2A binds 10 atoms of copper(I). Complexes with up to 12 atoms of Cu+ are observed, however the predominant form appears to be MT2A:10Cu+ (Banci et al. 2010, Chung et al. 2010). Metallothioneins and CuZn-SOD have the highest affinities of cellular proteins for copper(I), but metallothioneins are incapable of removing copper from other cellular enzymes (Banci et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20463663	Affinity gradients drive copper to cellular destinations Banci, L, Bertini, I, Ciofi-Baffoni, S, Kozyreva, T, Zovo, K, Palumaa, P	Nature	2010
20711450	The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons Chung, RS, Howells, C, Eaton, ED, Shabala, L, Zovo, K, Palumaa, P, Sillard, R, Woodhouse, A, Bennett, WR, Ray, S, Vickers, JC, West, AK	PLoS ONE	2010