Dopachrome transforms to DHI

Stable Identifier
R-HSA-5662706
Type
Reaction [transition]
Species
Homo sapiens
Compartment
melanosome lumen
ReviewStatus
5/5
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Dopachrome transforms to DHI
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Dopachrome spontaneously tautomerizes into 5,6-dihydroxyindole (DHI) via decarboxylation at physiological pH (Mason et al. 1948, Wakamatsu & Ito 1988, Kishida et al. 2015). This is usually a minor process of melanin synthesis in vivo. However, in human hair follicular melanocytes, it predominates (Commo et al. 2012).
Literature References
PubMed ID Title Journal Year
18920770 The chemistry of melanin. III. Mechanism of the oxidation of dihydroxyphenylalanine by tyrosinase

Mason, HS

J. Biol. Chem. 1948
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Authored
Jupe, S  (2015-01-13)
Reviewed
d'Ischia, M  (2015-02-13)
Ito, S  (2015-02-13)
Created
Jupe, S  (2015-01-13)
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