Dopachrome transforms to DHI

Stable Identifier
R-HSA-5662706
Type
Reaction
Species
Homo sapiens
Compartment
melanosome lumen
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Dopachrome transforms to DHI
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Dopachrome spontaneously tautomerizes into 5,6-dihydroxyindole (DHI) via decarboxylation at physiological pH (Mason et al. 1948, Wakamatsu & Ito 1988, Kishida et al. 2015). This is usually a minor process of melanin synthesis in vivo. However, in human hair follicular melanocytes, it predominates (Commo et al. 2012).

Literature References
PubMed ID Title Journal Year
18920770 The chemistry of melanin. III. Mechanism of the oxidation of dihydroxyphenylalanine by tyrosinase

Mason, HS

J. Biol. Chem. 1948
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Authored
Jupe, S  (2015-01-13)
Reviewed
d'Ischia, M  (2015-02-13)
Ito, S  (2015-02-13)
Created
Jupe, S  (2015-01-13)
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