Dopa is oxidized to dopaquinone by TYR

Stable Identifier
R-HSA-5662692
Type
Reaction [transition]
Species
Homo sapiens
Compartment
melanosome lumen
Synonyms
2 L-dopa + O2 => 2 L-dopaquinone + 2 H2O
ReviewStatus
5/5
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Dopa is oxidized to dopaquinone by TYR
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Dopa is a substrate of tyrosinase, which can oxidize it to dopaquinone (Young et al. 1974).
Literature References
PubMed ID Title Journal Year
4853153 Melanin. I. Kinetics of the oxidative cyclization of dopa to dopachrome

Young, TE, Griswold, JR, Hulbert, MH

J. Org. Chem. 1974
Participants
Input
Output
Participates
as an event of
Catalyst Activity

catechol oxidase activity of TYR:2xCu2+ [melanosome membrane]

Physical Entity
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
Activity
catechol oxidase activity (GO:0004097)
Orthologous Events
Dopa is oxidized to dopaquinone by TYR (Bos taurus)
Dopa is oxidized to dopaquinone by TYR (Caenorhabditis elegans)
Dopa is oxidized to dopaquinone by TYR (Canis familiaris)
Dopa is oxidized to dopaquinone by TYR (Dictyostelium discoideum)
Dopa is oxidized to dopaquinone by TYR (Gallus gallus)
Dopa is oxidized to dopaquinone by TYR (Mus musculus)
Dopa is oxidized to dopaquinone by TYR (Rattus norvegicus)
Dopa is oxidized to dopaquinone by TYR (Sus scrofa)
Dopa is oxidized to dopaquinone by TYR (Xenopus tropicalis)
Cross References
RHEA
Authored
Jupe, S  (2015-01-13)
Reviewed
Ito, S  (2015-02-13)
d'Ischia, M  (2015-02-13)
Hill, DP  (2025-03-26)
Created
Jupe, S  (2015-01-13)
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