Dopachrome is transformed to DHICA by DCT

Stable Identifier
R-HSA-5662660
Type
Reaction [transition]
Species
Homo sapiens
Compartment
melanosome lumen, melanosome membrane
ReviewStatus
5/5
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Dopachrome is transformed to DHICA by DCT
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Dopachrome is converted to DHICA by DCT (Dopachrome tautomerase, Tyrosinase-related protein 2) (Tsukamoto et al. 1992, Kroumpouzos et al. 1994, Bouchard et al. 1994).

Literature References
PubMed ID Title Journal Year
8048919 Functional analysis of the slaty gene product (TRP2) as dopachrome tautomerase and the effect of a point mutation on its catalytic function

Kroumpouzos, G, Hearing, VJ, Kobayashi, T, Urabe, K, Sakai, C

Biochem. Biophys. Res. Commun. 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

oxidoreductase activity of DCT:2xZn2+ [melanosome membrane]

Physical Entity
DCT:2xZn2+ [melanosome membrane] (Homo sapiens)
Activity
oxidoreductase activity (GO:0016491)
Orthologous Events
Dopachrome is transformed to DHICA by DCT (Bos taurus)
Dopachrome is transformed to DHICA by DCT (Caenorhabditis elegans)
Dopachrome is transformed to DHICA by DCT (Canis familiaris)
Dopachrome is transformed to DHICA by DCT (Danio rerio)
Dopachrome is transformed to DHICA by DCT (Dictyostelium discoideum)
Dopachrome is transformed to DHICA by DCT (Gallus gallus)
Dopachrome is transformed to DHICA by DCT (Mus musculus)
Dopachrome is transformed to DHICA by DCT (Sus scrofa)
Dopachrome is transformed to DHICA by DCT (Xenopus tropicalis)
Authored
Jupe, S  (2015-01-13)
Reviewed
d'Ischia, M  (2015-02-13)
Ito, S  (2015-02-13)
Created
Jupe, S  (2015-01-13)
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