Reactome | MT3 binds cadmium

MT3 binds cadmium

Stable Identifier

R-HSA-5662620

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The metallothionein binds 7 atoms of cadmium(II) in 2 clusters, 4 atoms at the C-terminal alpha domain and 3 atoms at the N-terminal beta domain (Palumaa et al. 2002, Palumaa et al. 2005, Wu et al. 2014). MT3 binds cadmium with a lower affinity than MT2A does (Palumaa et al. 2005). MT3 can bind more than 7 cadmium atoms, however the MT3:7Cd2+ complex is most prevalent (Palumaa et al. 2002, Palumaa et al. 2005). Exposure of MT3:7Cd2+ to nitric oxide causes release of cadmium (Wang et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
15698955	Metal binding of metallothionein-3 versus metallothionein-2: lower affinity and higher plasticity Palumaa, P, Tammiste, I, Kruusel, K, Kangur, L, Jörnvall, H, Sillard, R	Biochim. Biophys. Acta	2005
24973778	High level expression, efficient purification, and bioactivity of recombinant human metallothionein 3 (rhMT3) from methylotrophic yeast Pichia pastoris Wu, Q, Li, B, Wu, F, Yang, L, Li, S, Li, H, Wu, D, Cui, T, Tang, D	Protein Expr. Purif.	2014
18157556	The effect of nitric oxide on metal release from metallothionein-3: gradual unfolding of the protein Wang, H, Li, H, Cai, B, Huang, ZX, Sun, H	J. Biol. Inorg. Chem.	2008
11994011	Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperatively Palumaa, P, Eriste, E, Njunkova, O, Pokras, L, Jörnvall, H, Sillard, R	Biochemistry	2002