The metallothionein MT3 binds 7 zinc(II) atoms in 2 clusters, one cluster of 4 atoms at the C-terminal alpha domain and one cluster of 3 atoms at the N-terminal beta domain (Eriste et al. 2003, Knipp et al. 2005, Meloni et al. 2007, Meloni et al. 2008, Meloni et al. 2009, Wu et al. 2014). Though MT3 has a lower overall affinity for zinc than MT2A does (Palumaa et al. 2005), MT3 is capable of binding an additional zinc atom with a binding constant of 100 micromolar (Eriste et al. 2003, Palumaa et al. 2005, Meloni et al. 2009). Stoichiometries up to MT3:11Zn2+ have been observed but the MT3:7Zn2+ form is more stable and predominates (Palumaa et al. 2002, Eriste et al. 2003, Palumaa et al.).
Wu, Q, Li, B, Wu, F, Yang, L, Li, S, Li, H, Wu, D, Cui, T, Tang, D
Palumaa, P, Tammiste, I, Kruusel, K, Kangur, L, Jörnvall, H, Sillard, R
Knipp, M, Meloni, G, Roschitzki, B, Vasák, M
Meloni, G, Polanski, T, Braun, O, Vasák, M
Meloni, G, Faller, P, Vasák, M
Meloni, G, Sonois, V, Delaine, T, Guilloreau, L, Gillet, A, Teissié, J, Faller, P, Vasák, M
Palumaa, P, Eriste, E, Njunkova, O, Pokras, L, Jörnvall, H, Sillard, R
Eriste, E, Kruusel, K, Palumaa, P, Jörnvall, H, Sillard, R
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