The metallothionein MT3 binds 7 zinc(II) atoms in 2 clusters, one cluster of 4 atoms at the C-terminal alpha domain and one cluster of 3 atoms at the N-terminal beta domain (Eriste et al. 2003, Knipp et al. 2005, Meloni et al. 2007, Meloni et al. 2008, Meloni et al. 2009, Wu et al. 2014). Though MT3 has a lower overall affinity for zinc than MT2A does (Palumaa et al. 2005), MT3 is capable of binding an additional zinc atom with a binding constant of 100 micromolar (Eriste et al. 2003, Palumaa et al. 2005, Meloni et al. 2009). Stoichiometries up to MT3:11Zn2+ have been observed but the MT3:7Zn2+ form is more stable and predominates (Palumaa et al. 2002, Eriste et al. 2003, Palumaa et al.).
Sillard, R, Jörnvall, H, Kruusel, K, Palumaa, P, Kangur, L, Tammiste, I
Li, S, Cui, T, Wu, D, Li, H, Wu, F, Tang, D, Yang, L, Li, B, Wu, Q
Vasák, M, Knipp, M, Roschitzki, B, Meloni, G
Vasák, M, Braun, O, Meloni, G, Polanski, T
Vasák, M, Faller, P, Meloni, G
Guilloreau, L, Gillet, A, Vasák, M, Teissié, J, Faller, P, Delaine, T, Meloni, G, Sonois, V
Sillard, R, Njunkova, O, Jörnvall, H, Palumaa, P, Pokras, L, Eriste, E
Sillard, R, Jörnvall, H, Palumaa, P, Kruusel, K, Eriste, E
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